Pierre Fabre Medicament

Pierre Fabre S.a.

P. F. Medicament

Jean-Francois Patoiseau

Dennis C Bigg

Jean-Marie Autin

Henri Cousse

Wouter Koek

Elisabeth Dupont-Passelaigue

Andre Delhon

Gilbert Mouzin

Thierry Imbert

Jean-Pierre Rieu

Alain Duflos

Jean-Pierre Tarayre

Robert Kiss

Christian Faure

Pierre Sokoloff

Francoise Couret

Philippe Oms

Philippe Hatinguais

Gilbert Marcelon

The invention concerns novel 3-oxo-(2H)-1,2,4-triazine derivatives of general formula (I) in which R,represents: hydrogen, when A is an optionally substituted nitrogen atom; a linear or branched,-C,alkyl group; a C,-C,phenyl alkyl group, the phenyl ring being optionally substituted by one or several groups such as C,-C,alkyl, C,-C,alkoxy, halogen, trifluoromethyl. R,represents: hydrogen; a linear or branched C,-C,alkyl radical; a C,phenyl or phenylalkyl group, the phenyl ring being optionally substituted by one or several groups such as C,-C,alkyl, C,-C,alkoxy, halogen, trifluoromethyl. A represents an oxygen atom or a nitrogen atom optionally NR,substituted. R,represents hydrogen or a methyl group. B represents a group such as (IIa) in which Ar itself represents an aromatic structure such as phenyl, pyridyl or pyrimidyl, optionally substituted by one or several groups such as C,-C,alkyl, C,-C,alkoxy, hydroxy, trifluoromethyl or halogen and n can be whole numbers ranging between 3 and 5; (IIb) in which Ar is as defined in formula (IIa) and m can be a whole number ranging between 1 and 2; (IIc) in which R,represents hydrogen or a C,-C,alkyl group and n can be whole numbers ranging between 3 and 5.

3-oxo-2(H)-1,2,4-triazine derivatives as ligands of 5 HT1A receptors

Glycylanilide derivatives, their preparation and their application in

1,2-dihydro-2-oxo-3-aminoquinoxaline derivatives, their preparation and

3,5-dioxo-(2H,4H)-1,2,4-triazine derivatives as 5HT.sub.1A ligands

The application discloses pharmacologically-active 3-hydroxy-1-phenyl-1,4-dihydro-4-oxopyridazine compounds, derivatives thereof, a method for the preparation thereof, pharmaceutical compositions thereof, and a method of treating anxiety and other physiological abnormalities therewith.

3-hydroxy-substituted-1-phenyl-1,4-dihydro-4-oxopyridazines and

The present invention relates to compounds of the Formula I: ##STR1## wherein R is hydrogen, alkyl, cycloalkyl, phenyl, or alkylphenyl, and n is 2 through 4, the production thereof, pharmaceutical compositions thereof, and their use in antineoplastic therapy.

Spirocyclic N, O derivatives of cyclotriphosphazenes and their use in

The present invention relates to derivatives of 1-phenyl 1,4-dihydro 3-amino 4-oxo pyridazines of the general formula I: ##STR1## and the production thereof. It also concerns pharmaceutical compositions comprising as active principle a compound of general formula I and use thereof for treatment of central nervous system disturbances, especially as an anxiolytic.

Derivatives of 1-phenyl 1,4-dihydro 3-amino 4-oxo pyridazines, their

The invention concerns halo-biphenyl tertiary alcohols of the general formula: ##STR1## in which: X is chlorine or bromine in ortho or meta position.

Halo-biphenyl tertiary alcohols useful in therapy in the treatment of

A compound corresponding to formula (I): ##STR1## wherein X represents oxygen, sulphur or &gt;N--R',

Compounds of the benzoxepine series and sulphur- and nitrogen-containing

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Castres, France

Jean-Francois Patoiseau