Bio-rad Pasteur

Jean-Francois Hubert Delagneau

Stephane Jean Xavier Gadelle

Francois Yves Rieunier

François Yves Rieunier

Denis Marie Bernárd Chenebaux

Synthetic peptides of the monomer type with 13 to 33 amino acids, in linear form or in a form cyclized by means of inter-cysteine disulphide bridges, have the general formula (I):&#x394;-Z-TrpGlyCys-&#x398;-CysTyrThrSer-&#x3a9;&#x2003;&#x2003;(I)wherein &#x394; is a biotinyl radical, a biocytinyl radical, a hydrogen atom, an acetyl (CHCO&#x2014;) radical, an aliphatic chain which may contain one or two thiol, an aldehyde functional group, or an amine functional group, Z represents peptide sequence -&#x39e;-Ser-&#x39e;-, -&#x39e;-Gln-&#x39e;-, or -&#x39e;-Asn-&#x39e;-, wherein -&#x39e;represents a peptide sequence of 0 to 9 amino acids and -&#x39e;represents a peptide sequence of 0 to 5 amino acids, &#x398;is -Arg Gly Arg Leu Ile-(SEQ ID NO: 15), -Arg Gly Arg Leu Val-(SEQ ID NO: 16), -Arg Gly Lys Leu Ile-(SEQ ID NO: 17), -Arg Gly Lys Leu Val-(SEQ ID NO: 18), -Lys Gly Arg Leu Ile-(SEQ ID NO: 19), or -Lys Gly Arg Leu Val-(SEQ ID NO: 20), &#x3a9;, attached to the &#x2014;CO&#x2014; group of serine, is a hydroxyl (&#x2014;OH) radical, an amino (&#x2014;NH) radical, an alkoxy radical having 1 to 6 carbon atoms, a peptide sequence of formula Val-&#x3a3;-&#x3a8; wherein &#x3a3; represents a sequence of formula -(AA)-Trp Asn-(AA)-(AA) wherein (AA) represents an amino acid different from lysine, (AA) represents an amino acid, and (AA) is serine or a threonine residue, and &#x3a8;, attached to the &#x2014;CO&#x2014; residue of the free AAamino acid, is OH, NH, or an alkoxy radical having from 1 to 6 carbon atoms, and a peptide sequence of formula -Val-&#x3a8; wherein &#x3a8;, attached to the &#x2014;CO&#x2014; residue of valine, is OH, NH, or an alkoxy radical having from 1 to 6 carbon atoms.

Synthetic peptides useful in biological essays for detecting infections caused by group O HIV-1 viruses

Synthetic peptides of the monomer type with 13 to 33 amino acids, in linear form or in a form cyclized by means of inter-cysteine disulphide bridges, have the general formula (I):&#x394;-Z-TrpGlyCys-&#x398;-CysTyrThrSer-&#x3a9;&#x2003;&#x2003;(I)wherein &#x394; is a biotinyl radical, a biocytinyl radical, a hydrogen atom, an acetyl (CHCO&#x2014;) radical, an aliphatic chain which may contain one or two thiol, an aldehyde functional group, or an amine functional group, Z represents peptide sequence -&#x39e;-Ser-&#x39e;-, -&#x39e;-Gln-&#x39e;-, or -&#x39e;-Asn-&#x39e;-, wherein -&#x39e;represents a peptide sequence of 0 to 9 amino acids and -&#x39e;represents a peptide sequence of 0 to 5 amino acids, &#x398; is -Arg Gly Arg Leu Ile-(SEQ ID NO: 15), -Arg Gly Arg Leu Val-(SEQ ID NO: 16), -Arg Gly Lys Leu Ile- (SEQ ID NO: 17), -Arg Gly Lys Leu Val-(SEQ ID NO: 18), -Lys Gly Arg Leu Ile-(SEQ ID NO: 19), or -Lys Gly Arg Leu Val-(SEQ ID NO: 20), &#x3a9;, attached to the &#x2014;CO&#x2014; group of serine, is a hydroxyl (&#x2014;OH) radical, an amino (&#x2014;NH) radical, an alkoxy radical having 1 to 6 carbon atoms, a peptide sequence of formula Val-&#x3a3;-&#x3a8; wherein &#x3a3; represents a sequence of formula -(AA)-Trp Asn-(AA)-(AA) wherein (AA) represents an amino acid different from lysine, (AA) represents an amino acid, and (AA) is serine or a threonine residue, and &#x3a8;, attached to the &#x2014;CO&#x2014; residue of the free AAamino acid, is OH, NH, or an alkoxy radical having from 1 to 6 carbon atoms, and a peptide sequence of formula -Val-&#x3a8; wherein &#x3a8;, attached to the &#x2014;CO&#x2014; residue of valine, is OH, NH, or an alkoxy radical having from 1 to 6 carbon atoms.

Growing community of inventors

La Celle Saint Cloud, France

Jean-Francois Hubert Delagneau