Institut Pasteur

Evelyne Dufour

Jean-francois Huaulme

Anne Wisner

Catherine Rougeot

Marie-noelle Ungeheuer

Jean-Francois Huaulme

Marie-Noelle Ungeheuer

The invention relates to an in vitro method for prognosis, diagnosis or determination of the evolution of a condition involving an altered production of Basic Proline-rich Lacrimal Protein (BPLP) or of any of its maturation products, by detecting, or quantifying in a biological sample of a test subject, a BPLP protein or a maturation product thereof, and comparing the production of BPLP protein or maturation product with the production of the same in a biological sample of a control subject.

Pharmaceutical compositions containing peptides derived from human BPLP protein

Methods for treating pain by administering peptides derived from human basic proline-rich lacrimal protein

Method for detecting human BPLP protein or a maturation product thereof

The invention relates to a peptide that is a maturation product of the Basic Prolin-rich Lacrinal Protein (BPLP) or a peptide derivative of said maturation product, wherein the peptide or peptide derivative exhibits an inhibitory property against a metallo-ectopeptidase, especially NEP and/or APN. The present invention also relates to polynucleotides coding for said peptides and to antibodies directed against said peptides. Furthermore, the present invention relates to diagnostic and therapeutic uses of human BPLP protein and inhibitory peptides derived therefrom, polypeptides coding for human BPLP protein or peptides derived therefrom as well as antibodies directed against BPLP protein or peptides derived therefrom.

Peptides derived from human BPLP protein

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Paris, France

Jean-Francois Huaulme