Idenix Pharmaceuticals, Inc.

Centre National De La Recherche Scientifique

Universitè De Montpellier

Jean-Francois Griffon

Cyril B Dousson

Dominique Surleraux

Claire Pierra

Adel M Moussa

Gilles J Gosselin

David Dukhan

Francois-Rene Alexandre

Christophe Parsy

Benjamin Alexander Mayes

Jean-Laurent Paparin

Frederic Leroy

Alistair James Stewart

Houcine Rahali

Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 2'-chloro nucleosides according to Formula 2001: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein B, Z and PD are as described herein.

2'-chloro nucleoside analogs for HCV infection

Provided herein are phosphothiophene and phosphothiazole compounds, for example, of any of Formulae I, IA, IIA, IIIA, IVA, VA, VIA, VIIA, IB, IIB, IIIB, IVB, VB, VIB and VIIB disclosed herein, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host infected with HCV.

Phosphothiophene and phosphothiazole HCV polymerase inhibitors

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Teyran, France

Jean-Francois Griffon