Rhodia Chimie

Rhone-poulenc Chimie

Jean-Francis Spindler

Marc Taillefer

Henri-Jean Cristau

Pascal Philippe Cellier

Jean-Roger Desmurs

Georges Cordier

Vincent Schanen

Pierre Fouilloux

Nathalie Laurain

Danielle Gree

Maxime Garayt

Genevi&egrave;ve Padilla

Virginie Le Boulaire

René Gree

The invention relates to a novel method for producing nucleophilic substitutions, particularly of type SNAr and SN2. More specifically, the invention relates to the use as a fluorinating reaction medium of ionic liquid or fused salt comprising at least four carbon atoms. The invention can be used for the synthesis of fluoride derivatives.

Use of a composition of an ionic nature as a substrate reagent, a composition constituting a fluorination reagent and a method using same

The present invention concerns a process for arylating or vinylating or alkynating a nucleophilic compound. More particularly, the invention concerns arylating nitrogen-containing organic derivatives. The arylating or vinylating or alkynating process of the invention consists of reacting a nucleophilic compound with a compound carrying a leaving group and is characterized in that the reaction is carried out in the presence of an effective quantity of a catalyst based on a metallic element M selected from groups (VIII), (Ib) and (IIb) of the periodic table and at least one ligand comprising at least one imine function and at least one supplemental nitrogen atom as the chelating atoms.

Process for arylating or vinylating or alkynating a nucleophilic compound

The present invention concerns a process for arylating or vinylating or alkynating a nucleophilic compound. More particularly, the invention concerns arylating nitrogent-containing organic derivatives. The arylating or vinylating or alkynating process of the invention consists of reacting a nucleophilic compound with a compound carrying a leaving group and is characterized in that the reaction is carried out in the presence of an effective quantity of a catalyst based on a metallic element M selected from groups (VIII), (Ib) and (IIb) of the periodic table and at least one at least bidentate ligand comprising at least two chelating atoms, namely at least one oxygen atom and at least one nitrogen atom.

The invention concerns a halogenation in position meta of a phenol fuction. Said halogenation comprises a step which consists in halogenating an aromatic derivative of a medium or advantageously strong acid, the aromatic radical being a phenyl substituted in ortho and in para by functions attracting electrons by inductive effect. The invention is applicable to organic synthesis.

Halogenation of protected phenols in meta position

Process for the catalytic hydrogenation of nitriles to amines in the

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Lyons, France

Jean-Francis Spindler