Institut Merieux

Societe Anonyme Dite: Institut Merieux

Jean F Pla

Jacques C Liautaud

Robert A Plan

Paule A Gattel

Marie-France Makula

Andre J Debrus

Edward Shanbrom

Maryse Chanas

Procedure for the preparation of a concentrate of prothrombinogenic compound. This procedure, in which, starting from a source of prothrombinogenic compound, an adsorption is followed by an elution, is characterized by the fact that a source of prothrombinogenic compound and a source of antithrombin III (or AT III) is placed in contact with an adsorbing agent capable of adsorbing both the prothrombinogenic compound and antithrombin III, and that the foregoing occurs in the presence of heparin, at least during the elution stage, and that elution is carried out with an elution agent capable of eluting the prothrombinogenic compound, the AT III and heparin at the same time. Application of the product obtained, notably to the treatment of blood coagulation difficulties.

Prothrombin complex concentrates, preparation and application thereof

A method is disclosed for concentrating and purifying antihemophilic factor (AHF or Factor VIII), a cryoprecipitate is collected from frozen human plasma and cold washed with pyrogen-free distilled water or water saline. The washed cryoprecipitate is extracted with pyrogen-free distilled water, the prothrombin complex is removed and the fibrinogen is precipitated. The remaining purified solution is ultrafiltered to form a highly concentrated Factor VIII solution.

Method for concentrating and purifying antihemophilic factor or factor

Purified albumin is prepared from frozen placenta, placental blood or other hemolyzed blood by the steps of eliminating hemoglobin, eliminating enzymes and eliminating group substances.

Process for the preparation of purified albumin and albumin obtained by

Purified albumin is prepared from an albumin solution containing foreign or denatured proteins by heating the solution in the presence of caprylic acid at a pH of 4.8 - 5.25 at a temperature between 50.degree. - 64.degree. C. The amount of caprylic acid expressed in weight of sodium caprylate is between 15 - 30% by weight of the proteins in said solution.

Growing community of inventors

Sainte Foy Les Lyon, France

Jean F Pla