Centre National De La Recherche Scientifique

Universitéde Strasbourg

Amoneta Diagnostics

Jean De Barry

Raymond Ziessel

Gilles Ulrich

Thomas Bura

Alexandre Haefele

Corinne Mbebi-Liegeois

Francois Sellal

Corinne Liegeois

Agn&eacute;s Janoshazi

Arielle Ungerer

Yves L Boulanger

Monique Schmitz-Bourgeois

A biomarker for Alzheimer's disease (AD) comprising a complex of an A&#x3b2; amyloid peptide and a cell or a cellular membrane. Non-invasive methods for diagnosing Alzheimer's disease or monitoring its development or progression using this biomarker.

Biological complex specific for Alzheimer's disease detection in vitro and use thereof

The invention relates to novel fluorescent compounds derived from non-fluorinated dipyrromethene-boron, to a method for preparing same and to the use thereof for the fluorescent marking of biological molecules. The invention also relates to biological molecules marked with said fluorescent compounds, and to the use thereof in detection methods such as medical diagnosis methods. More particularly, the detection methods of the invention are particularly useful for diagnosing neurodegenerative diseases such as Alzheimer's disease.

Fluorescent boron-substituted dipyrromethenes and use thereof for diagnosis

The invention relates to methods for diagnosing Alzheimer's disease from a blood specimen. The method involves incubating a blood sample with a fluorescent probe that interacts with either protein kinase C (PKC) or protein kinase A (PKA), and measuring the fluorescence intensity in different conditions. Variation in the emission spectra data relative to those of the spectra obtained with healthy subjects is a discriminatory factor vis-&agrave;-vis Alzheimer's disease. The probes may recognize the catalytic site or the regulator domain of PKC or PKA, and may be coupled to a synthetic organic compound such as bis-indolmaleimide. In one aspect, the probes are lipidic, including probes prepared from phospholipid constituents of a cell membrane. In another aspect, the probes are proteinic or peptide probes of a membrane or cytoskeletal nature. Useful probes include derivatives of substrates for PKC or PKA.

Methods and kits for diagnosing Alzheimer's disease from a blood sample

Therapeutically active compositions of pseudo-peptide of

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Strasbourg, France

Jean De Barry