University of Pennsylvania

Inovio Pharmaceuticals, Inc.

Jean D Boyer

David B Weiner

Michele Kutzler

Velpandi Ayyavoo

Joo-Sung Yang

Andrew Y Choo

Jong J Kim

Andrew K Choo

Joo-Sung Room 62207 Dept Genetic Eng Yang

Bin Wang

Nucleic acid molecules comprising a nucleotide sequence encoding RANTES and fragments and variants thereof are disclosed. Additionally, nucleic acid molecules and compositions comprising the nucleotide sequence encoding RANTES and fragments and variants thereof in combination with nucleic acid sequences encoding immunogens are provided. Recombinant viral vectors comprising the nucleotide sequence encoding RANTES and fragments and variants thereof with or without a nucleic acid sequence encoding immunogens are also provided as are live attenuated pathogens comprising a nucleotide sequence encoding RANTES and fragments and variants thereof. Methods of modulating immune responses and of inducing an immune response against an immunogen are also disclosed.

Nucleic acid molecules encoding rantes, and compositions comprising and methods of using the same

Fusion proteins and nucleic acid molecules encoding fusion proteins are disclosed. Fusion proteins comprising non-IL-15 signal peptide linked to IL-15 protein sequences and fusion proteins comprising an IgE signal peptide linked to non-IgE protein sequences are disclosed. Vectors comprising such nucleic acid molecules; and to host cells comprising such vectors are disclosed as well as recombinant vaccines and live attenuated pathogens encoding fusion proteins, and methods of using the same, are disclosed. The immunomodulatory effect following delivery of IL-15 and CD40L, with or without immunogens, is disclosed as are various nucleic acid molecules and compositions thereof used for delivering such proteins and methods of using such compositions.

Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same

Growing community of inventors

Haddonfield, NJ, United States of America

Jean D Boyer