Centre National De La Recherche Scientifique

Universitè De Montpellier

Institut National De La Sante Et De La Recherche Medicale

Ecole Nationale Superieure De Chimie De Montpellier

Centre Hospitalier Universitaire De Nîmes

Centre Regional Hospitalier Universitaire De Nimes

Ecole Nationale Superieure De Chimie De Montpellier (Enscm)

Inserm

Université De Montpellier 1

Université De Montpellier 2

Jean Coudane

Xavier Garric

Michel R Vert

Benjamin Nottelet

Vincent Letouzey

Mahfoud Boustta

Claudia Montero-Menei

Renaud De Tayrac

Sarah El Habnouni

Katarina Marcincinova

Christine Ustariz

Salome Leprince

Anita Schulz Épouse Luxenhofer

Cedric Paniagua

Sebastien Blanquer

Vincent Darcos

Olivier Guillaume

Gregoire Schwach

Laurent Lemaire

Marie Morille

Stephanie Huberlant

Van-Thanh Tran

Marie-Claire Venier-Julienne

Salomé Leprince

Cédric Paniagua

Stéphanie Huberlant

Sébastien Blanquer

The present invention relates to an efficient method for grafting a properties-imparting compound onto a polymeric substrate containing carbon-hydrogen (C&#x2014;H) bonds using clip chemistry. The method of the invention includes coating the substrate with the properties-imparting compound and irradiating it with a reactive light source, and repeating this sequence at least once. The present invention further relates to surface-modified polymeric substrates grafted with a properties-imparting compound, in particular obtained with the method of the invention, medical devices comprising same, and non-medical of said surface-modified polymeric substrates.

Surface-modified polymeric substrates grafted with a properties-imparting compound using clip chemistry

Disclosed is a composition based on copolymers including at least one A-B block copolymer, wherein block A is a polyester and block B is a polyoxyethylene (PEG), and wherein the total molecular mass in weight of the PEG is higher than or equal to 50 kDa, and the ethylene oxide motif/ester motif molar ratio is between 0.5 and 5. The invention also relates to an anti-adhesive material including such a composition, used for the prevention of tissue adhesions and especially for the prevention of intrauterine synechiae.

Composition of diblock and triblock copolymers and the use thereof in the prevention of tissue adhesions

The invention relates to a hydrophobic thermoplastic copolymer which is in particular of use for manufacturing and/or coating medical devices, in particular implantable medical devices, characterized in that it is obtained by copolymerization, and in that it comprises at least one first monomer unit and at least one second monomer unit onto which is grafted a paramagnetic-ion-chelating ligand which can complex with such a paramagnetic ion or a paramagnetic-ion-chelating ligand which is complexed with such a paramagnetic ion, wherein the second monomer unit is grafted in sufficient amount for the copolymer to be visible in magnetic resonance imaging when it is complexed with said paramagnetic ion. The invention also relates to a method for obtaining said hydrophobic thermoplastic copolymer.

MRI-visible hydrophobic copolymer

A cell carrying microsphere composition, wherein the microsphere composition comprises a microspheric core comprising a triblock copolymer matrix A-B-A wherein A is selected from poly(lactide-co-glycolide) (PLGA) or polylactide (PLA) and B is poloxamer or poloxamine, wherein the microspheric core is coated with a cell adhesion coating and further comprises whole cells or cell fragments bonded to the cell adhesion coating, a process for the preparation of a cell carrying microsphere composition, and applications thereof.

Microsphere compositions, preparation method and applications thereof

The present invention relates to a hydrophobic polymer used in particular to produce and/or coat medical devices, in particular implantable medical devices, that are visible in magnetic resonance imaging, characterized in that it comprises at least one monomer unit on which is grafted a chelating ligand of a paramagnetic ion complexed with such a paramagnetic ion, said monomer unit having at least one carbonyl group, said monomer unit comprising, prior to grafting, at least one hydrogen atom in the &#x3b1; position of said at least one carbonyl group, and said grafting of the chelating ligand taking place in the area of said at least one hydrogen atom in the &#x3b1; position of said at least one carbonyl group.

Hydrophobic polymer for producing medical devices visible in MRI

Monomers with dilactone cycle, and corresponding polymers

Bioresorbable-polymer microspheres of hydroxy acid polymer free from

Growing community of inventors

Lattes, France

Jean Coudane