Oxis Isle of Man, Limited

Oxis International S.a.

Tetrahedron

Galderma Research & Development

Oxis International, Inc.

Tetrahedron Sas

Jean-Claude Y Yadan

Jean R Chaudiere

Marc E Moutet

Irene Erdelmeier

Jinzhu Xu

Georges Appere

Catherine Tailhan-Lomont

Jean-Claude Michel

Remi Lebel

Marc Gabriel Antoine

Dominique Gerard-Monnier

Irène Erdelmeir

Marc Moutet

The invention relates to a selenium compound. Said selenium compound has formula (I), where R=alkyl; R=H, RC(=0), ROC(=0), a-aminoacyl, CHSeCHCHCH(NH)C(=0), CHSeCHCHCH(OH)C(=0); X=OH, OR, NH, NRR, &#x3b1;-amino acid, CHSeCHCHCH(COOH)NH&#x2014;, CHSeCHCHCH(COOH)0-; R=alkyl; R=alkyl, aryl; R=H, alkyl, aryl; Rand Rwhich can together form a 5- or 6-membered cycloalkyl radical which can comprise a heteroatom; provided that when X=NH-terbutyl, R&#x2260;C(=0)CH. Said compound can be used as a pharmaceutical substance, in particular as an antitumour substance.

Organoselenium compounds, method for producing same, and pharmaceutical uses thereof in particular as antitumor agents

Pharmaceutical/cosmetic compositions containing a dermatologically effective amount of hyaluronic acid, at least one retinoid and/or salt and/or derivative thereof, at least one oligosaccharide and at least one inhibitor of hyaluronic acid degradation, formulated into a physiologically acceptable medium therefor, are useful for the treatment of wrinkles, fine lines, fibroblast depletions and scars.

Pharmaceutical/cosmetic compositions comprising hyaluronic acid and treatment of dermatological conditions therewith

The invention relates to the enrichment of non-photosynthetic micro-organisms with organic selenium, and more particularly with selenomethionine, from a compound of the seleno-hydroxyacid type such as 2-hydroxy-4-methylseleno-butanoic acid in the (D, L) form or in the form of an enantiomer, salt, ester, or amide derivative of said compound, and to the use of micro-organisms, particularly bacteria thus enriched in the fields of animal or human nutrition, cosmetics, or pharmaceuticals.

Non-photosynthetic micro-organisms enriched with organic selenium from seleno-hydroxyacid compounds and applications thereof in the field of nutrition, cosmetics and pharmacueuticals

The purpose of this invention is: The new compounds that are the subject of this invention satisfy the general formula (I): in which

Selenohydroxy acids and their derivatives, applications in nutrition, cosmetics and pharmaceutics

The invention is directed to novel cyclic organoselenium compounds useful as antioxidants, pharmaceutical compositions containing them, and methods for their preparation.

Cyclic organoselenium compounds, their preparation and their uses

Uses of novel organoselenium compounds with pro-oxidant activity

Compounds represented by the following formula I: ##STR1## in which: R.sup.1 to R.sup.5 can have various meanings of which alkyl, substituted or non-substituted aryl, and m is equal to 0 or 1, X is selected from (CR.sup.6 R.sup.7).sub.n in which n=0 or 1, and CO are disclosed. These compounds are useful as anti-tumor drugs, especially with pro-oxidizing activity.

Use of novel organoselenium compounds as pro-oxidizing agents, their

The invention concerns novel benzisoselen-azoline and -azine derivatives. These novel derivatives have the following general formula (II): ##STR1## where: R.sup.1 to R.sup.8 and R.sup.10 have various meanings, in particular H, alkyl, etc . . . ; ##STR2## Y.sup.- represents the anion of a pharmaceutically acceptable anion; n=0, 1; m=0, 1, 2; p=1, 2, 3; q=2, 3, 4; r=0, 1; and their pharmaceutically acceptable salts of acids or bases; there being no more than one substituent R.sup.9 in each molecule with general formula II. These novel derivatives can be used in medication.

Method for storing a biological organ transplant graft using a

The invention relates to 2-mercaptoimidazole derivatives substituted in the 4(or 5)-position. These 2-mercaptoimidazole derivatives are of the general formula (I) below: ##STR1## wherein: R.sub.1, R.sub.2, R.sub.5, R.sub.7 and R.sub.8 are hydrogen, a lower alkyl, an aralkyl or a substituted aralkyl, wherein at least one of R.sub.1 and R.sub.2 is hydrogen;

2-mercapto-imidazole derivatives substituted in position 4 (or 5) as

Organoselenium compounds with pro-oxidant activity and pharmaceutical

The objects of the present invention are:

Aromatic diselenides and selenosulfides, their preparation and their

Use of novel organoselenium compounds as pro-oxidizing agents their

Compounds having a benzisoselen-azoline and -azine structure, method for

According to the invention, the total mercaptans in an aqueous sample are assayed by means of the formation of a chromophoric substitution product between all the mercaptans present in the sample and a reagent corresponding to the general formula I: ##STR1## Reduced glutathione (GSH) is assayed in the form of a chromophoric thione formed specifically by alkalization from the substitution product formed above between GSH and the reagent. The concentration of mercaptans distinct from GSH is obtained by subtraction of the concentrations obtained in the preceding assays. Application to the assay of mercaptans and GSH, especially in the presence of other mercaptans, in particular in biological media.

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Paris, France

Jean-Claude Y Yadan