Science Union Et Cie

Science Union Et Cie, Societe Francaise De Recherche Medicale

Science Union Et Cie, Societe Francaise De Recherche Medical

Adir, S.a.r.l.

Adir Et Compagnie

Adir

Science Union Et Cie, Societe Francaise De Recherche Med.

Jean-Claude Poignant

Michel Laubie

Charles E Malen

Gilbert Regnier

Xavier B Pascaud

Roger Canevari

Pierre Hugon

Pierre Roger

Laszlo Beregi

Georges Remond

Michel Vincent

Monique Desnos

Michel Wierzbicki

Jean-Louis Peglion

Triazole compounds of the formula: ##STR1## in which: X and X', which are the same or different, each represents hydrogen, halogen, trifluoromethyl, C.sub.1 -.sub.5 alkyl, or C.sub.1 -.sub.5 alkoxy, or

N-(N'-phenylpiperazine)-alkyl triazole compounds having anxiolytic and

Benzodioxine compounds of the formula: ##STR1## in which Het is a five- or six-membered heterocyclic radical containing from one to three hetero atoms, and from one to three double bonds, optionally substituted by one or more alkyl or alkoxy radicals each from C.sub.1 to C.sub.5. These compounds and physiologically tolerable acid addition salts thereof may be used as medicines, especially in the treatment of psychoses.

(1-benzodioxin-6-ylmethyl)-4-substituted piperazines having

Compounds of the formula: ##STR1## in which: R.sub.1 and R.sub.2 each represent, independently of one another, hydrogen, halogen, alkyl or alkoxy having from 1 to 4 carbon atoms, sulphonamide possibly substituted by an alkyl radical having from 1 to 4 carbon atoms; or together methylenedioxy, n is 0 or 1,

Bicyclo (4.2.0) 1,3,5-octatriene compounds and use as .alpha.-adrenergics

Compounds corresponding to the general formula: ##STR1## in which X and Y identical or different, represent a hydrogen or a halogen atom, a lower alkyl, a lower alkoxy or a trifluormethyl group,

Tricyclic ethers, their preparation and the pharmaceutical compositions

This invention relates to novel tricyclic ethers, pharmaceutically acceptable addition salts and optical isomers therefrom. The compounds described herein are useful as psychotropic agents in the treatment of depression and anxiety. Also included herein are methods of preparing said compounds, pharmaceutical compositions including them and methods of treating human or animal beings by administering these pharmaceutical compositions.

Tricyclic ethers, their process of preparation and their use as medicines

Disubstituted piperazines of the formula ##STR1## in which n is 1 or 2,

Disubstituted piperazines

Disubstituted piperazines of the formula: ##STR1## in which: n is 1 or 2,

Disubstituted piperazines of the formula: ##STR1## wherein: ##STR2## is naphthyl, benzo [b] furanyl, benzo [b] thienyl, benzodioxolyl, benzodioxanyl, benzodioxacycloheptanyl, coumaranyl, chromanyl, .DELTA..sup.3 -chromenyl, thiochromanyl or .DELTA..sup.3 -thiochromenyl, X is nitrogen and simultaneously Y is oxygen or sulfur, or X is sulfur, imino (NH) or methylimino (N CH.sub.3) and simultaneously Y is nitrogen, and R is hydrogen, lower alkyl, phenyl, halophenyl, lower-alkylphenyl or lower alkoxyphenyl. These compounds possess interesting pharmacological and therapeutic properties, and may be used as medicines, especially in the treatment of hypertension, peripheral vascular disorders and Parkinson's disease.

This invention relates to novel .omega.-benzylamino alkanoic acids, to their salts with an organic or mineral base or with an organic or mineral acid. These alkanoic acids may be in a racemic form or resolved into their optically-active enantiomers. They are produced by condensing an oxoalkanoic acid with a benzylamine under reducing conditions. This invention also relates to .omega.-benzylamino alkanoic amides and to .omega.-benzylamino alkanoic acid esters. They have therapeutical use, namely in the psychotherapeutical field. They are utilized in the form of pharmaceutical compositions.

Benzylamino alkanoic acid derivatives, using compositions containing the

This invention relates to novel acetamides, the nitrogen of which is substituted with an amino lower alkyl chain. This invention also relates to a process for producing the said N-substituted acetamides. The end compounds have therapeutical utility and find a use as anti-convulsant agents.

Anti-convulsant N-ethanolamine diphenyl acetamides

Naphthyl derivatives of the formula: ##STR1## wherein: R.sub.1 is hydrogen, halogen, lower alkyl or lower alkoxy, and

1-Naphthylmethyl-4-(thiazolyl-2)-piperazines

Cyclopropylmethylamines which are substituted on the 2-position of nitrogen heterocycles so as to provide new compounds of the formula ##STR1## wherein A is oxygen, sulfur, or nitrogen; the other 'R' variables in general are hydrogen, lower-alkyl, cyclopropyl, or lower-alkyl substituted cyclopropyl; and the n's are the numbers 0 to 3, inclusive, and acid addition salts thereof, are disclosed. The compounds are cardiovascular agents, which are depressive of the central nervous system. Their effects include hypnosis, analgesia, and neuro-modulation. They can be used as anti-hypertensive agents.

2-Amino oxazolines and process for making the same

Heterocyclic compounds of the formula: ##STR1## WHEREIN ONE OF Y and Z is CH, the other being N, A is a straight or branched saturated hydrocarbon chain from C.sub.2 to C.sub.6 inclusive, X is chlorine, hydroxy, alkoxy or alkylthio each from C.sub.1 to C.sub.5 inclusive, R is hydrogen, alkyl, hydroxyalkyl or dihydroxyalkyl each from C.sub.1 to C.sub.3 inclusive, R' is halogen, alkyl or alkoxy each from C.sub.1 to C.sub.3 inclusive and n is 0, 1 or 2. These compounds, their optical isomers and their physiologically tolerable salts are used as medicines especially in the treatment of central nervous system disorders.

2-(Substituted heterocyclic amine)benzoic acids

This invention relates to ortho-alkoxy anilines having the amino group substituted with an amino lower alkyl carboxylic residue, as well as their physiologically-compatible acid-addition salts and their optically-active isomers. This invention also relates to processes for making the same in which an ortho-alkoxy aniline is reacted with a lower alkanoic acid or a functional derivative thereof. The compounds of the invention have therapeutical utility namely for the prevention or treatment of digestive disorders and gastric ulcers.

Alkoxy anilides and pharmaceutical compositions

The invention relates to novel spirodecane derivatives and more specifically to novel azaspirodecane diones. The invention also provides process for producing said azaspirodecane diones which consists mainly in cyclizing a disubstituted glutaronitrile or a glutaric acid in the presence of an amino compound. The compounds of the present invention have interesting pharmacological properties and they find therapeutical uses.

Growing community of inventors

Bures, Yvette, France

Jean-Claude Poignant