Galderma Research & Development

Laboratoire Theramex

Estetra S.p.r.l.

Mithra R&d Sa

Jean-Claude Pascal

Laurence Clary

Claire Bouix-Peter

Sandrine Chambon

Nicolas Rodeville

Eric Terranova

Laurent Chantalat

Olivier Roye

Carine Rosignoli

Jean-Guy Boiteau

Denis Carniato

Pascale Mauvais

Jean Lafay

Remi Delansorne

Itaru Suzuki

Marlene Schuppli-Nollet

Jacques Paris

Maurits E Vandewalle

Pierre Jean De Clercq

Marlène Schuppli-Nollet

Paule Bonnet

Sebastien Daver

Nathalie Adje

Philippe Maillos

Marlène Schuppli

Alain Piasco

Veronique Parnet

Christine Marty

Véronique Parnet

Sébastien Daver

The present invention relates to a process for the preparation of a compound of formula (I) comprising the steps of a) reacting a compound of formula (II) with a silylating or an acylating agent to produce compound of formula (III), wherein Pis a protecting group selected from R&#x2014;Si&#x2014;RRor RCO&#x2014;, Ris a group selected from Calkyl or Ccycloalkyl, each group being optionally substituted by one or more substituents independently selected from fluoro or Calkyl; R, Rand Rare each independently a group selected from Calkyl or phenyl, each group being optionally substituted by one or more substituents independently selected from fluoro or Calkyl; b) halogenation or sulfinylation of the compound of formula (III) to produce a compound of formula (IV); wherein X is halo, or &#x2014;O&#x2014;SO&#x2014;R, and Ris a group selected from Caryl or heteroaryl, each group being optionally substituted by one or more substituents independently selected from chloro or Calkyl; c) dehalogenation or desulfinylation of the compound of formula (IV) to produce compound of formula (V); and d) reacting the compound of formula (V) with a reducing agent to produce compound of formula (I). 

Process for the production of estetrol intermediates

The present invention relates to a process for the preparation of a compound of formula (I) said process comprising the steps of: a) reacting a compound of formula (II), with an acylating or a silylating agent to produce a compound of formula (III), wherein Pand Pare each independently a protecting group selected from RSi&#x2014;RR, or RCO&#x2014;, wherein Ris a group selected from Calkyl or Ccycloalkyl, each group being optionally substituted by one or more substituents independently selected from fluoro or Calkyl; R, Rand Rare each independently a group selected from Calkyl or phenyl, each group being optionally substituted by one or more substituents independently selected from fluoro or Calkyl; b) reacting the compound of formula (III) in the presence of palladium acetate or a derivative thereof to produce compound of formula (IV); and c) reacting the compound of formula (IV) with a reducing agent to produce compound of formula (I). 

The present invention relates to novel compounds derived from oxoazetidine corresponding to general formula (I) to the compositions containing same, to the process for preparation thereof and to the use thereof in pharmaceutical or cosmetic compositions. 

Oxoazetidine derivatives, process for the preparation thereof and use thereof in human medicine and in cosmetics

Benzenesulfonamide compounds having a structure of formula (I) are described. Also described, are methods for synthesizing the compounds and to the use thereof in pharmaceutical compositions for human or veterinary medicine and in cosmetic compositions.

Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics

The present invention relates to novel benzene-carboxamide compounds having a structure that corresponds to the general formula (I) below: and also to their method of synthesis and to their use in pharmaceutical compositions intended for use in human or veterinary medicine or else to their use in cosmetic compositions. 

4-alkoxy-N-(2-hydroxycarbamoyl-2-piperidinyl-ethyl)-benzamide compounds as selective TACE-inhibitors for the treatment of inflammatory diseases

Compounds of the following general formula (I): are described. Also described, are processes of their preparation and their use in therapeutic applications.

Peroxide derivatives, their process of preparation and their use in human medicine and in cosmetics for the treatment or prevention of acne

The present invention relates to a process for the preparation of a compound of formula (I), hydrates or solvates thereof.

Process for the production of estetrol

The use of compounds in the treatment of skin disorders is described. In particular, compounds having the general formula (I): are described. A process for preparing such compounds and their cosmetic or dermatological use are also described. The described compounds can act as bactericides. As a result, they can be useful in the treatment of conditions associated with the presence of bacteria, more specifically of

Dibenzoyl peroxide derivatives, preparation method thereof and cosmetic or dermatological compositions containing same

Compounds derived from oxoazetidine corresponding to general formula (I) compositions containing same, processes for their preparation and their use in pharmaceutical or cosmetic compositions are described.

Oxoazetidine derivatives, process for the preparation thereof and use thereon in human medicine and in cosmetics

Compounds of the following general formula (I): are described. Also described, are methods of preparing the compounds and their use in therapeutics.

Derivatives of novel peroxides, method of preparation thereof and use thereof in human medicine as well as in cosmetics for the treatment or prevention of acne

Novel 3-phenyl acrylic acid compounds have the following general formula (I): and are formulated into pharmaceutical compositions for administration in human or veterinary medicine (in dermatology, as well as in the field of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or into cosmetic compositions.

3-phenyl acrylic acid compound activators of type PPAR receptors and pharmaceutical/cosmetic compositions comprised thereof

4-(heterocycloalkyl)benzene-1,3-diol compounds are described corresponding to general formula (I) below: Also described, are compositions including the same, processes for preparation thereof and to the use thereof in pharmaceutical or cosmetic compositions for use in the treatment or prevention of pigmentary disorders.

4-(heterocycloalkyl) benzene-1,3-diol compounds as tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and also in cosmetics

Growing community of inventors

Nice, France

Jean-Claude Pascal