Medesis Pharma

Medesis Pharma Sa

Centre National De La Recherche Scientifique

Universitè De Montpellier

Maurel Sante

Jean-Claude Maurel

Elsa Compte

Cyril Lavaud

Yannick Guari

Jaime Francisco Angulo-Mora

Jérôme Long

Caroline Bauer

Olivier Gremy

Laurent Miccoli

Joulia Guari

Jean-Marc Chapuis

Jean-Jacques Mongold

Nicolas Jouy

Lorraine Benigno-Anton

Sophie Grives-Jerphagnon

Patrick Maurel

Jerome Long

Claude-Alain Cudennec

The disclosure relates to the treatment and/or prevention of radiation damage by administering a reverse micelle system.

Treatment and prevention of injury due to radiation exposure

The present invention relates to a method for in situ preparation of cyano-bridged coordination polymers as metal nanoparticles within a biocompatible reverse micellar system by mixing at least two reverse micellar systems, each one containing at least one metal salt precursor. The invention also relates to the stabilization of theses nanoparticles by using a biocompatible reverse micellar system. This system takes part of the synthesis as a nanoreactor which comprises at least an acylglycerol, a sterol, lecithin, ethanol and water for the preparation of stable cyano-bridged metal nanoparticles without any use of additional stabilizer agent.

In situ preparation of cyano-bridged metal nanoparticles within a biocompatible reverse micellar system

The present invention relates to reverse-micellar systems comprising at least an active agent, an acylglycerol, a sterol, lecithin, ethanol and water, for use in chelation and/or sequestering of a radionuclide and/or a metal in a patient. The invention also relates to the reverse-micellar systems and to pharmaceutical compositions comprising said reverse-micellar systems.

Use of a reverse-micellar system for delivering chelators of radionuclides and metals

The present invention relates to reverse micelle system based on sterols, acylglycerols, phospholipids or sphingolipids and metal ions. Reverse micelle system of the invention is able to cross mucosa and cellular membranes. It thus allows vectorization of metal ions to target sites. It is advantageously useful in the pharmaceutical and dietetic fields.

Reverse micelle system comprising metal ions and use thereof

The present invention relates to reverse micelle system based on sterols, acylglycerols, phospholipids or sphingolipids and nucleic acids. The reverse micelle system of the invention is able to cross mucosa and cellular membranes. It thus allows vectorization of nucleic acids to target sites. It is advantageously useful in the pharmaceutical and dietetic fields.

Reverse micelle system comprising nucleic acids and use thereof

The present invention relates to a method for the preparation of reverse micelles based on sterols, acylglycerols and metal salt and to reverse micelles obtained thereby. They are advantageously useful in the pharmaceutical and dietetic fields.

Reverse micelle compositions for delivery of metal cations comprising a diglyceride and a phytosterol and method of preparation

The present invention relates generally to reverse-m ice liar system comprising a hydrosoluble therapeutically active agent. Reverse micelles according to the invention are particularly useful to deliver drugs. The present invention also relates to pharmaceutical composition comprising said reverse micelles and methods for preparing the same.

Reverse micelles based on phytosterols and acylglycerols and therapeutic uses thereof

Diglyceride and sterol based organometallic complexes and pharmaceutical

Growing community of inventors

Castries, France

Jean-Claude Maurel