Schering Aktiengesellschaft

Jean-Claude Hilscher

Johannes Platzek

Heinz Gries

Klaus Nickisch

Heribert Schmitt-Willich

Bernd Raduchel

Orlin Petrov

Gerhard Sauer

Helmut Wachtel

Thomas Frenzel

Herbert H Schneider

Hans Bauer

Hubert Vogler

Wolfgang Kehr

Andreas Muhler

Hanfried Arnold

Reinhold Wieske

Derivatized DTPA complexes, pharmaceutical agents containing these

Process for the production of C-substituted diethylenetriamines

(2-Haloergolinyl)-N',N'-diethylurea derivatives of Formula I ##STR1## and the salts thereof, wherein R is hydrogen, alkyl of up to 6 carbon atoms, or alkenyl of up to 3 carbon atoms,

(2-Haloergolinyl)-N'-N'-diethylurea compounds useful as medicinal agents

3-Hemisulfate sodium salts of 17.alpha.-hydroxy steroids of the formula ##STR1## wherein R.sub.1 is H, CH.sub.3 or C.sub.2 H.sub.5 and .DELTA. is one or more additional double bonds optionally present in the B and/or C rings are produced by treating a 17-mono ester of a carboxylic acid of up to 15 carbon atoms of the corresponding 3,17.alpha.-dihydroxy steroid with the reaction product of pyridine or like amine and sulfur trioxide or reactive functional derivative thereof and, without isolation thereof, saponifying the resultant reaction product with alkali, preferably a sodium alcoholate or hydroxide in a lower alcohol.

Process for the preparation of 3-hemisulfate-17.alpha.-hydroxy steroids

Ethers of aromatic steroids are cleaved to regenerate the hydroxy group with aluminum hydride, dialkylaluminum hydride or trialkylaluminum.

Steroid ether splitting

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Berlin, Germany

Jean-Claude Hilscher