Syntex Pharmaceuticals, Ltd.

Syntex (u.s.a.) Inc.

Laroche Navarron S.a.

Jean-Claude G Pascal

Gary Mccort

Henri Pinhas

Serge Beranger

Dominique Blondet

Colette Favier

Arthur F Kluge

Robin D Clark

Jurg R Pfister

Arthur M Strosberg

Roger Whiting

John M Armstrong

Leslie Patmore

Francoise Gellibert

Francedillaoise Gellibert

Compounds of the formula: ##STR1## wherein: m is 0 or 1;

Heterocyclic derivatives in the treatment of ischaemia and related

Compounds of the formula: ##STR1## wherein A, R.sup.1, R.sup.2, R.sup.3 and m are defined as in the specification or a pharmaceutically acceptable acid addition salt or N-oxide thereof, are calcium and sodium channel antagonists useful for treating mammals having a variety of disease states, such as stroke, epilepsy, hypertension, angina, migraine, arrhythmia, thrombosis, embolism, and also for treatment of spinal injuries.

Heterocyclic derivatives in the treatment of Ischaemia and related

The invention provides a new and efficient process for preparing 2,4(5)-substituted or 1,2,4-substituted imidazole derivatives. The invention also provides a process for preparing substituted aminoalkylimidazole derivatives, useful for the treatment of mammals having a variety of disease states, including stroke, epilepsy, hypertension, angina, migraine, arrhythmia, thrombosis, embolism, and the like.

Process for the preparation of 1,2,4-substituted imidazoles and related

The invention provides a new and efficient process for preparing 2,4(5)-substituted or 1,2,4-substituted imidazole derivatives. The invention also provides a process for preparing substituted aminoalkylimidazole derivatives, useful for the treatment of mammals having a variety of disease states, including stroke, epilepsy, hypertension, angina, migraine, arrhythmia, thrombosis, embolism, and the like. The invention also relates to novel aminoalkylimidazole compounds.

Carbostyril derivatives of Formula I: ##STR1## wherein: m is 0, 1, or 2;

Carbostyril compounds connected via an oxyalkyl group with a piperidine

Compounds having the formula ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the definitions given herein, are useful as antiarrhythmic agents.

N-phenyl-4-phenyl-1-piperazinecarboxamidines and related compounds as

Novel compounds of the general formula ##STR1## and the pharmaceutically acceptable esters and acid addition salts thereof, wherein:

Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl

New compounds of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein M is selected from the group consisting of hydrogen, morpholino, benzylamino, di-n-lower alkylamine, n-lower alkylamine, and aryl piperazino;

Piperazine derivatives of theophylline

New compounds of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein Z.sub.1 and Z.sub.2 are each independently selected from the group consisting of CH.sub.2, CHOB and C.dbd.O, wherein B is selected from the group consisting of hydrogen and alkanoyl;

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Cachan, France

Jean-Claude G Pascal