Forschungszentrum Juelich Gmbh

Onefocus Vision, Inc.

Universitaet Zu Koeln

Anm Adaptive Neuromodulation Gmbh

Elenza, Inc.

Other

Micronit Microfluidics B.v.

Jean-Christophe Roulet

Urban Schnell

Peter Alexander Tass

Amitava Gupta

Birgit Utako Barnikol

Stefan Troller

Steven B Waite

Oleksandr Popovych

Hans-Joachim Freund

Joel Niederhauser

Jean-Noel Fehr

Michel Saint-Ghislain

Ronald D Blum

Walter Doll

Roland Michaely

Karim Haroud

Jean-Noël Fehr

Marko Theodoor Blom

Christian Hauptmann

Johannes Oonk

Jeroen Haneveld

Ronny Van 't Oever

Marinus Bernardus Olde Riekerink

Laetitia Mayor

Peter Tijssen

Thomas Von Bueren

Hendrik Jan Hildebrand Tigelaar

Marcus Goetz

Bernhard Pelz

Stefan Fischer

Michel Saint-ghislain

Ronny Van 'T Oever

A meniscus shaped lens module comprises one or more structures that decrease an amount of pressure or force to move one or more surfaces of the lens module and increase a separation distance of anterior and posterior surfaces of the module in order to provide an increase in optical power. A lens structure of the module comprises one or more of a pattern of a surface of a central chamber, a meniscus, a reduced diameter or a soft material in order to provide increased amounts of curvature of an outer contact lens surface with decreased amounts of pressure. The pattern can be formed in one or more of many ways, and may comprise one or more of folds, patterning, bellows or concertinaed surface of an optically transmissive material having a substantially uniform thickness such as a sheet of a membrane material.

Fluidic module for accommodating soft contact lens

A device and method are provided for treating a patient with vibration and/or tactile and/or thermal stimuli. The device includes first and second stimulating units for generating first and second stimuli respectively. The stimuli are vibration and/or tactile and/or thermal stimuli, and each of the stimuli is repeated on average at a frequency of 1 to 60 Hz. The stimuli are generated partly at different times.

Apparatus and method for treating a patient using vibration stimuli, tactile stimuli and/or thermal stimuli

A device and method for desynchronizing a patient's neuronal brain activity in which the neuron population is firing in a pathologically synchronized manner. The device includes a stimulation unit that generates an acoustic stimulation signal that includes both a first tone and a second tone. The first tone is provided to shift the phase of the neuronal brain activity of a first subpopulation of the neuron population relative to the phase of the neuronal brain activity of a second subpopulation of the neuron population when the first tone is acoustically received by the patient. Further, the second tone is provided to shift the phase of the neuronal brain activity of the second subpopulation relative to the phase of the neuronal brain activity of the first subpopulation when the second tone is acoustically received by the patient. As a result, the acoustic stimulation signal desynchronizes the stimulated neuron population.

Device and method for auditory stimulation

Many modern implantable ophthalmic devices include electronic components, such as electro-active cells, that can leak harmful substances into the eye and/or surrounding tissue. In the implantable ophthalmic devices disclosed herein, electronic components are hermetically sealed within cavities formed by bonding together two or more glass wafers. Bonding the glass wafers together with laser fusion bonding, pressure bonding, or anodic bonding creates a seal that leaks at a rate of less than about 5&#xd7;10Pa mswhen subjected to a helium leak test. Hermetically sealed feedthroughs formed of conductive material running through channels in the wafers provide electrical connections to components inside the sealed cavities. In some cases, the conductive material has a coefficient of thermal expansion (CTE) that is roughly equal to (e.g., within 10% of) the CTE of the glass wafers to minimize leakage due to thermally induced expansion and contraction of the conductive material and the glass wafer.

Hermetically sealed implantable ophthalmic devices and methods of making same

The invention relates to a device for the stimulation of thermal receptors in the skin of a patient by means of thermal stimuli. The device comprises a plurality of noninvasive stimulation units for irradiating the skin of the patient with electromagnetic radiation, wherein thermal stimuli are produced by absorption of the electromagnetic radiation in the skin of the patient and the wavelength range of the electromagnetic radiation emitted by the stimulation units can be adjusted. The device also comprises a control unit for controlling the stimulation units.

Device and method for stimulation by means of thermal stimuli

The invention relates to method for bonding at least two substrates, for example made from glass, silicon, ceramic, aluminum, or boron, by using an intermediate thin film metal layer for providing the bonding, said method comprising the following steps of: a) providing said two substrates; b) depositing said thin film metal layer on at least a part of a surface of a first substrate of the two substrates; c) bringing a surface of the second substrate into contact with said thin film metal layer on said surface of the first substrate such that a bonding between the second substrate and the thin film metal layer on the first substrate is provided; and d) at least locally strengthening the bonding between the second substrate and the thin film metal layer on the first substrate. The invention also relates to a device comprising two substrates, for example made from glass, silicon, ceramic, aluminum, or boron, and an intermediate thin film metal layer.

Method of bonding two substrates and device manufactured thereby

A device and method for providing stimulation signals that reset the phase of the neuronal activity of neurons in a patient's brain. The device includes a control unit; and a stimulation unit that has a plurality of stimulation elements, and each stimulation element generates visual stimulation signals that reset the phase of the neuronal activity of the neurons when the signals are taken up via an eye of a patient and transmitted to neurons that are exhibiting a pathologically synchronous and oscillatory neuronal activity. The control unit is further capable of actuating the stimulation unit such that the stimulation elements generate the visual stimulation signals with a time offset in respect to one another and/or with differing phase and/or with differing polarity.

Device and method for visual stimulation

Many modern implantable ophthalmic devices include electronic components, such as electro-active cells, that can leak harmful substances into the eye and/or surrounding tissue. In the implantable ophthalmic devices disclosed herein, electronic components are hermetically scaled within cavities formed by bonding together two or more glass wafers. Bonding the glass wafers together with laser fusion bonding, pressure bonding, or anodic bonding creates a seal that leaks at a rate of less than about 5&#xd7;10Pa mswhen subjected to a helium leak test. Hermetically sealed feedthroughs formed of conductive material running through channels in the wafers provide electrical connections to components inside the sealed cavities. In some cases, the conductive material has a coefficient of thermal expansion (CTE) that is roughly equal to (e.g., within 10% of) the CTE of the glass wafers to minimize leakage due to thermally induced expansion and contraction of the conductive material and the glass wafer.

A device and method for desynchronizing a patient's neuronal brain activity involving a neuron population firing in a pathologically synchronized manner. The device includes a stimulation unit configured to generate an acoustic stimulation signal to stimulate the neuron population when the acoustic stimulation signal is aurally received by the patient. Furthermore, the acoustic stimulation signal has a first frequency and a second frequency, with the first frequency provided to reset the phase of the neuronal brain activity in a first sub-population of the stimulated neuron population, and the second frequency provided to reset the phase of the neuronal brain activity in a second sub-population of the stimulated neuron population.

A device with a control unit and a plurality of stimulation units configured to be implanted in the body of a patient and generate optical stimuli, wherein the optical stimuli reset the phase of the neuronal activity of the neurons during the stimulation of neurons exhibiting abnormally synchronous and oscillatory neuronal activity, and the control unit is configured to actuate the stimulation units such that at least two of the stimulation units reset the phases of the respectively stimulated neurons at different times.

Device and method for stimulating neuronal tissue by means of optical stimuli

Growing community of inventors

Bern, Switzerland

Jean-Christophe Roulet