Hybrigenics S.a.

Institut Pasteur

Les Laboratories Servier

Les Laboratoires Servier

Laboratoire Biodim

Hybrigenics

Cellvir

Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Université Paris Descartes

Hivih

Inserm-Transfert Sa

Jean-Christophe Rain

Pierre Legrain

Olivier Geneste

John Hickman

Philippe Guedat

Frédéric Colland

Micheline Fromont

Laurent Daviet

Etienne Formstecher

Xavier Jacq

Richard Benarous

Rémi Delansorne

Stéphane Emiliani

Guillaume Blot

Clarissa Berlioz-torrent

Matteo Colombo

Catherine Borg-Capra

Guillaume Boissy

Stefania Vallese

Ilaria Peretto

Stefano Vignando

Richard Bennett

Luc Selig

Clarisse Berlioz-Torrent

Stephane Emiliani

Clarisse Berlioz Torrent

The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use.

Cysteine protease inhibitors and their therapeutic applications

The present invention relates to protein-protein interactions involved in AIDS. More specifically, the present invention relates to complexes of polypeptides or polynucleotides encoding the polypeptides, fragments of the polypeptides, antibodies to the complexes, Selected Interacting Domains (SID&#xae;) which are identified due to the protein-protein interactions, methods for screening drugs for agents which modulate the interaction of proteins and pharmaceutical compositions that are capable of modulating the protein-protein interactions.

Human immunodeficiency virus integrase&#x2014;Transportin&#x2014;SR protein&#x2014;protein interactions

The invention relates to a method of screening and identifying modulators of the protein interaction between new peptides and anti-apoptotic members of the Bcl-2 protein family. The modulators identified on the basis of this method are administered to patients with cancer in order to bring about apoptotic-type and/or autophagic-type programmed cell death in those patients.

Peptides which interact with anti-apoptotic members of the Bcl-2 protein family, and uses

The invention relates to a method of identifying modulators of programmed cell death, comprising an interaction between a motif of Beclin protein and an anti-apoptotic member of the family of Bcl-2 proteins and the detection of said interaction be means of fluorescence polarization. The modulators identified on the basis of said method are administered to cancer patients in order to induce apoptotic- and/or autophagic-type programmed cell death. The invention also relates to a motif of the Beclin protein which can interact with an anti-apoptic member of the family of Bcl-2 proteins and to the use thereof in order to induce programmed cell death in a cancer patient.

Motif of the beclin protein which interacts with anti-apoptotic members of the Bcl-2 protein family, and uses

The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use wherein R3, R4, R5, R6, Y, Het1, T, U, V, W, X, Ru, Rv and Rw are as defined in claim

Tetracyclic inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications

Human immunodeficiency virus integrase-LEDGF p75 isoform protein-protein interactions

Inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications

The invention relates to the identification of a new peptide interacting with the anti-apoptotic proteins Bcl-2, Bcl-W and/or Bcl-XL, and also to screening methods allowing identification of modifiers of those interactions.

Peptide interacting with anti-apoptotic proteins of the Bcl-2 family

The present invention concerns collections of recombinant cell clones derived from a prokaryotic genome, more particularly fromgenome, useable for two-hybrid systems and methods to produce such collections. The invention further relates to then identification ofprotein-protein interactions and to the application of said collections of recombinant cell clones and said identified proteins interactions to the pharmaceutical and diagnostic field.

Collection of prokaryotic DNA for two hybrid systems Helicobacter pylori protein-protein interactions and application thereof

The present invention is directed to a method for selecting a prey polypeptide that is able to interact with a bait polypeptide of interest, to a prey polynucleotide encoding the prey polypeptide as well as to the prey polypeptide itself. The invention also concerns plasmids used for performing the method of the invention as well as prokaryotic or eukaryotic recombinant host organisms containing such plasmids and also a collection of said recombinant host organisms consisting in a DNA library, such as a collection of recombinant haploid. Finally, the invention is also directed to a technical medium containing the whole information concerning the interactions between metabolically related bait and prey polypeptides and/or polynucleotides coding for bait and prey polypeptides.

Fast and exhaustive method for selecting a prey polypeptide interacting with a bait polypeptide of interest: application to the construction of maps of interactors polypeptides

The present invention is directed to a method for selecting a prey polypeptide that is able to interact with a bait polypeptide of interest, to a prey polynucleotide encoding the prey polypepetide as well as to prey polypeptide itself. The invention also concerns plasmids used for performing the method of the invention as well as prokaryotic or eukaryotic recombinant host organisms containing such plasmids and also a collection of said recombinant host organisms consisitng in a DNA library, such as a collection of recombinant haploid . Finally, the invention is also directed to a technical medium containing the whole information concerning the interaction between metabolically related bait and prey polypeptides and/or polynucleotides coding for bait and prey polypeptides.

The present invention is directed to a method for selecting a prey polypeptide that is able to interact with a bait polypeptide of interest, to a prey polynucleotide encoding the prey polypeptide as well as to the prey polypeptide itself. The invention also concerns plasmids used for performing the method of the invention as well as prokaryotic or eukaryotic recombinant host organisms containing such plasmids and also a collection of said recombinant host organisms consisting in a DNA library, such as a collection of recombinant haploid,Finally, the invention is also directed to a technical medium containing the whole information concerning the interactions between metabolically related bait and prey polypeptides and/or polynucleotides coding for bait and prey polypeptides.

Growing community of inventors

Ermont, France

Jean-Christophe Rain