Universitéde Liége

Massachusetts Institute of Technology

Jean-Christophe Monbaliu

Klavs F Jensen

Jie Chen

Ping Zhang

Timothy F Jamison

Andrea Adamo

Allan Stuart Myerson

David R Snead

Mohsen Behnam

Shin Yee Wong

Nopphon Weeranoppanant

Torsten Stelzer

Romaric Gerardy

Diego Collin

Thomas Toupy

Victor-Emmanuel Kassin

Eve Marie Revalor

Nelly Ntumba Tshibalonza

Morgan Hans

The invention provides a method for synthesizing a compound of formula wherein each R independently represents an optionally substituted aryl, heteroaryl, alkyl, perfluoroalkyl, cycloalkyl, alkoxy, aryloxy, acyl, carboxyl, hydroxyl, halogen, amino, nitro, cyano, sulfo or sulfhydryl group, in ortho, meta or para position to the cycloalkylamine moiety; Rand Reach independently represents a hydrogen atom, a lower alkyl group or a cycloalkyl group; Rrepresents a hydrogen group, substituted aryl, heteroaryl, alkyl, perfluoroalkyl, cycloalkyl, alkoxy, aryloxy group; Y represents an oxygen atom, a sulfur atom, a NH group, a NRgroup or a CHgroup;Rrepresents a hydrogen atom or an alkyl, aryl or a heteroaryl group; and n and m each independently represents an integer from 1 to 5; or a pharmaceutically acceptable salt thereof; or a precursor thereof; wherein the method comprises one or more of the following steps: (a) reacting a compound of formula (II) wherein R, R, Y, n and m are as defined above in relation to the compound of formula (I) with an oxygenating agent, a first additive and a second additive in a solvent in a fluidic network or in a batch process under thermal and/or photochemical conditions to form a compound of formula (III): wherein R, R, Y, n and m are as defined above in relation to the compound of formula (I), (b) reacting a compound of formula (III) with a nitrogen containing nucleophile in the presence of a third additive and/or a solvent in the fluidic network or in a batch process under thermal conditions to form a compound of formula (IV): wherein R, R, R, R, Y, n and m are as defined above in relation to the compound of formula (I); and/or(c) reacting a compound of formula (IV) in a fluidic network or in a batch process, optionally in the presence of a fourth additive, under thermal conditions to form a compound of formula (I); wherein one or more of steps (a), (b) and/or (c) is carried out in a fluidic network that comprises micro- and/or meso-channels having an internal dimension of from 100 &#x3bc;m to 2000 &#x3bc;m.

Ketamine flow synthesis

Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.

Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients

The invention provides a method for synthesizing a compound of formula wherein each R independently represents an optionally substituted aryl, heteroaryl, alkyl, perfluoroalkyl, cycloalkyl, alkoxy, aryloxy, acyl, carboxyl, hydroxyl, halogen, amino, nitro, cyano, sulfo or sulfhydryl group, in ortho, meta or para position to the cycloalkylamine moiety; Rand Reach independently represents a hydrogen atom, a lower alkyl group or a cycloalkyl group; Rrepresents a hydrogen group, substituted aryl, heteroaryl, alkyl, perfluoroalkyl, cycloalkyl, alkoxy, aryloxy group; Y represents an oxygen atom, a sulfur atom, a NH group, a NRgroup or a CHgroup; wherein R, R, Y, n and m are as defined above in relation to the compound of formula (I) with an oxygenating agent, a first additive and a second additive in a solvent in a fluidic network or in a batch process under thermal and/or photochemical conditions to form a compound of formula (III): wherein R, R, Y, n and m are as defined above in relation to the compound of formula (I), wherein R, R, R, R, Y, n and m are as defined above in relation to the compound of formula (I); and/or

A continuous-flow process for the production of allyl compounds by deoxydehydration of glycerol includes: Recovering the thermolysis products at the outlet and separating the at least one allyl compound from the other thermolysis products.

Process for the production of allyl compounds by deoxydehydration of glycerol

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Esneux, Belgium

Jean-Christophe Monbaliu