UniversitÉde Strasbourg

Jawaharlal Nehru Centre for Advanced Scientific Research

Jean-Christophe Cassel

Tapas Kumar Kundu

Anne-Laurence Boutillier

Snehajyoti Chatterjee

Muthusamy Eswaramoorthy

Pushpak Mizar

Chantal Mathis

Romain Neidl

Mohankrishna Dalvoy Vasudevarao

Vedamurthy Bhusainahalli Maheshwarappa

The present invention is in relation to a composition including nanosphere and histone acetyltransferase (HAT) activator. The nanosphere is carbon nanosphere (CSP) which is intrinsically fluorescent and the HAT activator is N-(4-Chloro-3-trifluoromethyl-phenyl)-2-n-propoxy-benzamide. The N-(4-Chloro-3-trifluoromethyl-phenyl)-2-n-propoxy-benzamide is covalently conjugated with the carbon nanosphere. The present invention further relates to a process for obtaining a composition including carbon nanosphere and Histone acetyltransferase (HAT) activator [N-(4-Chloro-3-trifluoromethyl-phenyl)-2-n-propoxy-benzamide]. The composition is capable of crossing blood brain barrier and inducing histone acetylation in brain. Further, the composition is capable of increasing neurogenesis, as well as improving long-term memory formation. The composition manages pathological conditions to a subject in need thereof, such as aging-related, neurodegenerative diseases (Alzheimer's in particular), neurological disorders, depression or other kinds of diseases in which increased HAT activity, neurogenesis and/or memory improvement would benefit.

Nanosphere-histone acetyltransferase (HAT) activator composition, process and methods thereof

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Strasbourg, France

Jean-Christophe Cassel