Choay, S.a.

Agence Nationale De Valorisation De La Recherche (anvar)

Sanofi

Agence Nationale De Valorisation De La Recherche

Harvard College

Institut National De La Sante Et De La Recherche Medicale

Sanofi Sa

Sanofi (societe Anonyme)

Agence Nationale De Valorisation

D.r.o.p.i.c.

Jean Choay

Jean-Claude Lormeau

Maurice Petitou

Louis A Chedid

Pierre Lefrancier

Edgar Lederer

Francoise Marguerite Audibert

Pierre G Sinay

Jean Goulay

Monique Parant

Jean-Claude Jacquinet

Jean-Francois Petit

Arlette Adam

Rita Ciorbaru

Claude Merser

Fabrielle Ellouz

Dominique Juy

Edgar Sache

Edmond G Vairel

Michael Sela

Camille G Wermuth

Pierre M Roger

Jean-Paul Fournier

Claude Carelli

John R Pappenheimer

James M Krueger

Manfred L Karnovsky

Michel Level

Henri Lucien Febvre

Francis Toulemonde

Alain Martin

Marie T By Goulay, Heir

Claude Raby

Jean Goulay, Deceased

Jean C Lormeau

Paul Trolard

Marie A By Goulay, Heir

Gerard By Goulay, Heir

Pierre Le Francier

Jean-Pierre Duclos

Mahmoud Nassr

Jean-Louis Amiot

Mireille Sakouhi Nee Cousin

Marcel Derrien

Francine Parant

The oligosaccharides of the invention are composed essentially of chains:

Process for recovering heparinic oligosaccharides with an affinity for

Method for obtaining biologically active mucopolysaccharides by controlled depolymerization of heparin, wherein the quantity of products generating nitrous acid is selected so that those products are totally consumed when the desired depolymerization degree is reached.

Method for obtaining biologically active mucopolysaccharides of high

According to the process of the invention, a glycosaminoglycan is used in the form of a salt soluble in an organic medium and is subjected to the action of a given sulfation agent.

Process for the sulfation of glycosaminoglycans, the sulfated

The compositions of the invention are composed of fragments of heparin consisting essentially of repeated disaccharide sequences corresponding to the regular regions of heparin and possessing a MW between 4,800 and 9,000. These compositions can be used for the regulation of physiological systems.

Low molecular weight heparins of regular structure, their preparation

The invention relates to derivatives with a uronic acid structure having substituents selected among a reactive group, a functionalisable group and --OH functions blocked by protective groups. These derivatives are useful for preparing glycosides, particularly enzyme substrates.

Derivatives of the uronic acid

Sulphonamides derived from diarylmethanes, the processes for preparing

Novel processes for synthesizing acid mucopolysaccharide fragments having from 2-12 saccharides and substantially pure products of a single structure produced thereby. Condensation are disclosed between a first protected saccharide and a second protected saccharide to form a protected condensation product having units linked in the manner found in chondroitin sulfate and dermatan sulfate and having protecting groups thereon which allow selective positioning of functional groups, in particular sulfate, at desired positions. Other condensations are disclosed in which a protected condensation product is formed which can be elongated, and has protecting groups thereon which allow selective positioning of functional groups, in particular sulfate, at desired positions. Also disclosed is a process for selectively positioning functional groups on a protected acid mucopolysaccharide having from 2-12 units.

Method for carrying out the organic synthesis of oligosaccharides

Short chained ligosaccharides of high structural homogeneity constituted essentially by hexasaccharides of the formula: ##STR1## in which R represents a hydrogen atom or the --SO.sub.3.sup.31 group. These hexasaccharides have a highly selective activity on certain steps in blood coagulation and are useful as anti-thrombotic medicaments.

Short chained oligosaccharides having biological properties, a process

The invention relates to a process for the organic synthesis of oligosaccharides constituting or comprising fragments of acid mucopolysaccharides comprising the reaction of two compounds constituted or terminated by units of glucosamine structure and of uronic acid structure respectively, said units being specifically substituted. This process particularly enables valuable anticoagulant drugs to be obtained.

Process for the organic synthesis of oligosaccharides and derivatives

Mucopolysaccharides biologically active and more specific than heparin, particularly with respect to the blood factor Xa. These mucopolysaccharides may be obtained by partial depolymerization, under controlled conditions, of heparin, by the action of a chemical agent such as nitrous acid. The conditions implemented allow the preparation of mucopolysaccharides having a USP titer lower than that of the starting heparin and a Yin-Wessler titer at least equal to that of said heparin. These products may be used particularly as antithrombotic drugs.

Mucopolysaccharides having biological properties, preparation and

The oligosaccharides of the invention contain or are constituted by a tetrasaccharide enchainment of the formula: ##STR1## in which R.sub.1 represents an organic anion, R.sub.2 is identical to R.sub.1 or represents a hydrogen atom, N.sub.1 and N.sub.2 represent a functional amino group.

Oligosaccharides and their biological applications

The oligosaccharidic fractions of the invention are soluble in an hydro-alcoholic mixture 50/50 (v/v) in which is added 0.5% NaCl, at pH 3.8, are constituted by chains the majority of which have 2 to 14 sugar units, are terminated by end units with a 2,5-anhydromanno structure and are devoid or practically devoid of anti-thrombotic activity.

Oligosaccharidic fractions devoid or practically devoid of

The medicaments of the invention contain in their active principle, oligosaccharides of low molecular weight corresponding to or including heparin fragments.

Medicaments favoring the properties of blood flow and their use in

1,4.alpha.disaccharides of formula: ##STR1## with Z representing a nitrogenous functional group,

Disaccharides formed by patterns having a glucosamine and uronic acid

Biological compositions which induce sleep of the slow-wave type which comprise biological carriers and sleep-inducing muramyl peptides such as acetylmuramyl-L-alanyl-D-isoglutamine and derivatives thereof and methods of using such compositions.

Somnogenic compositions and method of use

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Paris, France

Jean Choay