Ludwig Institute for Cancer Research Limited

Jean-Charles Cerottini

Pedro Romero

Danila Valmori

Immanuel F Luescher

Fabienee Anjuere

Andreas Layer

A method for inducing proliferation of cytolytic T cells is described.

Isolated nona- and decapeptides which bind to HLA molecules, and the use thereof

Nucleic acid molecules which encode decapeptides which are defined by an HLA-A2 binding motif are disclosed. Also disclosed are expression vectors which include these nucleic acid molecules.

Isolated nucleic acid molecules which encode peptides that bind to HLA molecules, and uses thereof

The invention relates to variant peptides which bind to HLA molecules, leading to lysis of cells via cytolytic T cell lines. The variants are based upon NY-ESO-1 peptides. The peptides can be incorporated into immune tetramers, which are useful as T cell sorters.

NY-ESO-1 peptide derivatives, and uses thereof

Nonapeptides and decapeptides which bind to HLA molecules and provoke proliferation of cytolytic T cells are disclosed. The decapeptides terminate in Valine, and are restricted in their first three amino acid positions. Other useful nonapeptides are also disclosed.

Isolated decapeptides which bind to HLA molecules

Method for provoking proliferation of cytolytic T cells via the use of decapeptides which complex with HLA-A2 molecules

Cytolytic T cells specific to complexes J HLA-A2 molecules and peptides are described as are methods for provoking the cytolytic T cells. The peptides of SEQ ID NOS: 13, 14 and 15 are preferred peptides.

Isolated nona-and decapeptides which bind to HLA molecules, and the use thereof

Isolated nona- and decapeptides which bind to HLA molecules, and the use

The invention relates to methods for making synthetic, photoreactive peptides and their use. A photoreactively labelled amino acid is incorporated into the peptide. The resulting peptide, when compared to the non-labelled form, is not impaired with respect to its ability to bind an MHC molecule.

Growing community of inventors

Epalinges, Switzerland

Jean-Charles Cerottini