Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Jean-Charles Arnault

Sylvie Chevillard

Philippe Bergonzo

Samuel Saada

Hugues Girard

Romain Grall

Jozo Delic

Julien Delchevalrie

Tristan Petit

Romain Bachelet

Vesna Simic

Delphine Lazaro

Dominique Tromson

Methods for treating a thin film made from a conductive or semiconductive material may improve the crystalline quality thereof. Such methods may include: supplying a substrate including, on one of the faces thereof, a thin film of the material; and biased plasma treating the assembly formed by the substrate and the thin film at a given temperature and for a given time, so as to obtain a crystalline reorganization over a depth of the thin film, the biased plasma treatment including an electrical biasing of the thin film and an exposure of the film thus biased to a hydrogen plasma, the biased plasma treatment being implemented at a temperature that is below the melting points of the thin film and of the substrate.

Treatment of a thin film by hydrogen plasma and polarisation in order to improve the crystalline quality thereof

The present invention relates to the use of nanodiamonds as drugs generating free radicals, in particular for treating tumors. The invention is based on generating free radicals on the surface of the nanodiamonds when they are exposed to radiation, for example ionizing radiation. In order to increase the effectiveness of the nanodiamonds, the nanodiamonds can be complexed with a radiosensitizing agent, such as a chemical molecule or an interfering RNA targeting a repairing gene.

Use of nanodiamonds for generating free radicals for therapeutic purposes under radiation

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Rambouillet, France

Jean-Charles Arnault