Sanofi

Sanofi-synthelabo

Jean C Breliere

Xavier Emonds-Alt

Georges Garcia

Didier Van Broeck

Pascual Ferrara

Raymond Paul

Christine Lebouteiller

Jorge Rosenfeld

The present invention relates to the use of compounds capable of displacing tritiated cis-N-cyclohexyl-N-ethyl &lsqb;3-(3-chloro-4-cyclohexylphenyl)-allyl&rsqb;amine from its receptors for the preparation of pharmaceutical compositions intended to combat cell proliferation.

Use of amines to produce drugs for preventing tumor cell proliferation

The present invention relates to products of the formula ##STR1## where R.sub.1 is H or alkyl, n is an integer from 0 to 10, and R.sub.2 is chosen from amongst H, unsubstituted or substituted alkyl radicals, a ##STR2## group, a substituted or unsubstituted phenyl radical, a ##STR3## group, where X is oxygen or sulfur, or a heterocyclic radical with 5 or 6 members, which may or may not be fused to a benzene ring and R.sub.3 is H or OH. The present invention also relates to a process for the preparation of the products of the formula (I), and to the drugs, having in particular an anti-inflammatory effect, containing a product of formula (I).

Anti-inflammatory products derived from methylene-diphosphonic acid, and

The present invention relates to products of the formula ##STR1## where R.sub.1 is H or alkyl, n is an integer from 0 to 10, and R.sub.2 is chosen from amongst H, unsubstituted or substituted alkyl radicals, a ##STR2## a substituted or unsubstituted phenyl radical, a ##STR3## where X is oxygen or sulfur, or a heterocyclic radical with 5 or 6 members, which may or may not be fused to a benzene ring and R.sub.3 is H or OH. The present invention also relates to a process for the preparation of the products of the formula (I), and to the drugs, having in particular an anti-inflammatory effect, containing a product of the formula (I).

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Montpellier, France

Jean C Breliere