Novasep

Novasep S.a.

Jean Blehaut

Wilhelm Hauck

Harlene Marks

Roger-Marc Nicoud

Roger Marc Nicoud

Fr&eacute;d&eacute;ric Charton

The invention relates to a chromatography device comprising: The invention also relates to processes for separating at least two compounds of a fluid to be chromatographed and to methods of adjusting the position of the piston with respect to the surface of the chromatographic bed using the chromatography device. The invention has the advantage of allowing effective separation of the compounds of the fluid to be chromatographed while ensuring that the bed is protected.

Protection of the chromatographic bed in dynamic axial compression chromatography devices

The invention concerns a chromatographic device including a column () for receiving a chromatographic bed () through which flow a first fluid; a piston () sliding inside the column () an exerting pressure on the bed (), a chamber () containing a second fluid exerting pressure on the piston (); a regulator () for the pressure exerted by the piston () on the bed based on the pressure inside the chamber (), on the flow pressure on the first fluid at the intake of the column () and on a reference pressure of the bed (). Said device enables to separate at least two compounds to be subjected to chromatographic analysis, while adjusting the pressure exerted on the chromatographic bed. The device efficiently uses the chromatographic bed while protecting it.

Protective device for the chromatographic bed in dynamic axial compression chromatographic columns

The invention concerns a method for separating from a mixture two optical isomers using a simulated moving bed including an assembly of columns divided into at least three successive zones. The amount of charge injected is greater than that of the state of a predetermined reference state. The discharge flow is greater than that of the predetermined reference state if it is required at least to preserve the purity of the less immobilized enantiomer. The discharge flow is less than that of the reference state if it is required to preserve the purity of the more immobilized enantiomer.

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Bryn Mawr, PA, United States of America

Jean Blehaut