Synthelabo

Jean Bertin

Jonathan Reid Frost

Alexander E Wick

Bernard Gaudilliere

Regis Dupont

Jean Rousseau

Patrick Andre Lardenois

Salomon Z Langer

Corinne Rousselle

Alfred Saarmets

Johannes Schoemaker

A compound, in the form of a pure optical isomer or a mixture thereof, of formula (I): ##STR1## in which: Z represents a group of formula --CH.sub.2 --, --C(CH.sub.3).sub.2 --, --CH.dbd.CH--, --(CH.sub.2).sub.2 --, --(CH.sub.2).sub.3 --, --NH-- or --N(CH.sub.3)CH.sub.2 --, in which the nitrogen is bonded to the carbonyl group;

Derivatives of (1-hydroxy-2-piperidylalkyl-indol-2-ones, 2-quinolinones,

Ifenprodil and its analogues are useful for the treatment of psychoses such as schizophrenia.

Method of treatment of psychotic disorders

Compounds of the formula: ##STR1## wherein R.sub.1 is hydrogen, halogen, trifluoromethyl, alkyl, hydroxyl, alkyoxy, benzyloxy, alkanoyloxy, or benzoyloxy, or when R.sub.2 is hydroxyl or methoxy in the 4-position and R.sub.3 is hydrogen, R.sub.1 may also represent hydroxymethyl carbamoyl or alkoxycarbonyl,

Therapeutically useful 1-phenyl-2-piperidinoalkanol derivatives

Compounds of general formula (I) ##STR1## wherein R1 represents a phenyl, halophenyl, methylphenyl, ethylphenyl, methoxyphenyl, trifluoromethylphenyl or naphthyl group, R2 represents hydrogen or a methyl or phenyl group, and R3 represents hydrogen or a benzyl group, except compounds in which R1 is a phenyl or 4-fluorophenyl group, R2 is hydrogen and R3 is hydrogen or a benzyl group, and their pharmaceutically acceptable acid addition salts have useful anti-depressant and anti-ischaemic properties.

Furo 3,2-c pyridine derivatives and their use in treating depression and

Compounds of the formula: ##STR1## wherein R.sub.1 represents hydrogen, chlorine or methoxy, R.sub.2 represents hydrogen, methyl or benzyl, and R.sub.3 and R.sub.4 represent hydrogen, or R.sub.3 represents methyl and R.sub.4 represents hydrogen or R.sub.3 represents hydrogen and R.sub.4 represents methyl, are new compounds useful in therapy as they possess an antianoxic activity.

Therapeutically useful 3,7a-diazacyclohepta[j,k]fluorene derivatives

Compounds of the general formula: ##STR1## wherein R.sub.1 represents hydrogen, chlorine or methoxy, R.sub.2 represents hydrogen, methyl or benzyl, and R.sub.3 and R.sub.4 represent hydrogen, or R.sub.3 represents methyl and R.sub.4 represents hydrogen, or R.sub.3 represents hydrogen and R.sub.4 represents methyl, with the exception of those compounds wherein R.sub.1, R.sub.3 and R.sub.4 each represent a hydrogen atom simultaneously, are new therapeutically useful compounds; they possess an antianoxic activity.

Growing community of inventors

Clamart, France

Jean Bertin