Merrell Dow Pharmaceuticals

Merrell Pharmaceuticals, Inc.

Jean-Bernard Ducep

Charles Danzin

Brigitte Lesur

Jean-Francois Nave

Detlef Jacobi

Karin Jund

Process for making (2S,5S)-5-fluoromethylornithine

This invention relates to novel N-derivatives of 1-deoxy nojirimycin, to the method for their preparation and to their use in the treatment of diabetes and the use against retro-viruses, particularly in the treatment of acquired immuno-deficiency syndrome (AIDS).

N-derivatives of 1-deoxy nojirimycin

.alpha.-glucosidase inhibitors

Fluorinated arachidonic derivatives are 5-lipoxygenase inhibitors which have the useful pharmacologic activity as antiallergy and anti-inflammatory agents and are useful for treating, for example, asthma, anaphylaxis, allergy, rheumatoid arthritis, and psoriasis and cardiovascular diseases.

Fluorinated arachidonic acid derivatives

This invention relates to novel N-derivatives of 1-deoxy-nojirimycin, to the processes for their preparation and to their end-use applications, particularly as to their use in the treatment of diabetes.

This invention relates to novel N-glycosyl derivatives of 1,4-dideoxy-1,4-imino-D-arabinitol, to the chemical processes for their preparation, to their .alpha.-glucosidase inhibiting properties, and to their end-use application in the treatment of diabetes, obesity and those diseases associated with retroviruses, particularly the HIV virus reported to be the causative of the acquired immune deficiency syndrome (AIDS).

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Sundhoffen, France

Jean-Bernard Ducep