Roussel Uclaf

Jean-Bernard Chazan

Jean-Claude Gasc

Daniel Coussediere

The present invention has as its objects a new derivative of the aminoglycoside family, namely N.sub.1 [L-(-)2-hydroxy-4-amino butyroyl]4-0[2',6'-diamino 2',6'-didesoxya, D glucopyranosyl]6-0[3'-methylamino 3',4',6'-tridesoxy .alpha., D-xylohexopyranosyl]2-desoxy streptamine, as well as its mineral or organic acid addition salts, its process of preparation and methods of treatment using the same.

Desoxystreptamine derivatives, salts, pharmaceutical compositions and

There are disclosed pharmaceutically-active aminoglycosides comprising 4-O-[2',6'-diamino 2',3',6'-tridesoxy .alpha.,D-ribohexopyranosyl] 6-O-[3'-methylamino 3',4',6'-tridesoxy .alpha.,D-xylohexopyranosyl] 2-desoxystreptamine of the formula: ##STR1## and the addition salts thereof with mineral acids or organic acids. Also disclosed are methods for preparation of the novel products as well as certain novel intermediate products. There are also disclosed pharmaceutical compositions in which the novel products are the active agents and a method for the treatment of bacteria infections in humans and animals.

Antibiotic aminoglycosides, processes of preparation and pharmaceutical

There are disclosed pharmaceutically-active aminoglycosides comprising 4-O-[2',6'-diamino-2',6'-didesoxy-.alpha.-D-glucopyranosyl] 6-O-[3'-methylamino-3',4',6'-tridesoxy-.alpha.-D-xylohexopyranosyl] 2-desoxy streptamine of the formula: ##SPC1## And the addition salts thereof with mineral acids or organic acids. Also disclosed are methods for preparation of the novel products as well as certain novel intermediate products. There are also disclosed pharmaceutical compositions in which the novel products are the active agents as well as methods for use of compositions as antibiotic agents.

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Paris, France

Jean-Bernard Chazan