Societe De Conseils De Recherches Et D'applications Scientifiques (s.c.r.a.s.)

Other

Centre National De La Recherche Scientifique

Societe D'expansion Scientifique Expansia

Ipsen Pharma S.a.s.

Bionumerik Pharmaceuticals, Inc.

Centre National De La Recherche Scientifique-Cnrs

Ipsen Pharma

Jean-Bernard Cazaux

Eric Manginot

Christine Le Breton

Dennis Bigg

Guy Bertrand

Olivier Lavergne

Jacques Pommier

Anne-Marie Liberatore

Christophe Lanco

Didier Bourissou

Alain Rolland

Francesc Pla Rodas

Jerry Harnett

Blanca Martin-Vaca

Heinz Gornitzka

Anca Dumitrescu

Gerard Ulibarri

Olivier Guerret

Roland Cherif-Cheikh

Jean-Marc Kamenka

G&eacute;rard Ulibarri

Frederic Lacombe

Gérard Ulibarri

R&eacute;gis Reau

Frédéric Lacombe

Marc Veyrat

Francis Diancourt

Jean-Luc Faure

St&eacute;phanie Goumri

Michel Dafniet

Hanh Nguyen

Lidija Vranicar

Hanh Nguyen Ngoc

Alexandre Louchkoff

Charles Brigati

Martin-Vaca Blanca

A catalytic lactide and glycolide copolymerization system comprising a trifluoromethane sulfonate as a catalyst and copolymerization additive and a copolymerization process.

Catalytic lactide and glycolide (co)polymerization system

The invention concerns the use of zinc derivatives of general formula (I) wherein: Lrepresents a group of formula: &#x2014;E(R)(R')(R&#x2033;), &#x2014;E(R) (R&#x2032;) or &#x2014;E(R); E is an atom of group 15; Land Lindependently represent a group of formula: &#x2014;E(R)(R&#x2032;)(R&#x2033;), &#x2014;E(R)(R&#x2032;) or &#x2014;E(R), or together form a chain of formula &#x2014;L&#x2032;&#x2014;A&#x2014;L&#x2032;&#x2014;; A represents a saturated or unsaturated chain comprising one, two or three elements of group 14; L&#x2032;and L&#x2032;independently represent a group of formula &#x2014;E(R)(R&#x2032;) &#x2014;E(R) or &#x2014;E&#x2014;; Eis an element of group 14; Eis an element of group 15; Eis an element of group 16; R, R&#x2032;, R&#x2033;, R, R&#x2032;and Rrepresent various groups, as (co) polymerisation catalysts of cyclic esters 

Use of zinc derivatives as cyclic ester polymerization catalysts

A compound of the formula wherein the substituents are defined as in the specification which compounds are useful in the treatment of cancer.

Analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them

A subject of the present invention is new compounds having a lanthanide and having a tridentate ligand, a process for their preparation and their use in particular as polymerization catalysts.

Polymerization catalysts

The invention relates to a method for preparing polyesters A containing several mid-chain free acid functions by ring-opening polymerisation in the presence of a chain initiator: the benzyl diester of the tartaric acid, the phenyl radical of which is optionally substituted. A: aliphatic based on cyclic esters such as lactides and glycolides.

Method for preparing polyesters having intrachain free acid functions

The use of stannylenes and germylenes of general formula (I) wherein: M represents a tin or geranium atom; Land Lindependently represent a group of formula: -E(R) (R') (R&#x2033;), -E(R) (R&#x2032;) or -E(R)) or together form a chain of formula -L&#x2032;-A- L&#x2032;; A represents a saturated or unsaturated chain comprising one, two or three elements of group 14; L&#x2032;and L&#x2032;, represent, independently, a group of formula: -E(R) (R&#x2032;)-, E(R)- or -E-; Eis an element of group 14; Eis an element of group 15; Eis an element of group 16; R, R&#x2032;, R&#x2033;, R, R&#x2032;and Rrepresent variable groups as polymerization catalysts of heterocycles.

Use of stannylenes and germylenes as polymerization catalysts for heterocycles

Compositions for treating cancer comprising an amount of a camptothecin with a 7-ring &#x3b2;-hydroxy lactone ring of the formula wherein the substituents are defined as in the specification sufficient to treat cancer.

The invention concerns a novel method for industrial preparation of disodium 2,2'-dithiobis(alkylsulphonates), and in particular disodium 2,2&#x2032;-dithiobis(ethanesulphate) (dimesna). Said novel method is summarized by the reaction diagram (A). In diagram (A), Hal represents a halogen atom, and preferably a bromine atom; M represents a sodium or potassium atom; and n represents an integer ranging between 0 and 2.

Method for preparing disodium 2,2'-dithiobis(ethanesulphonate)

The invention relates to new compounds having an element of group 12 and having a tridentate ligand, a process for their preparation and their use in particular as a polymerization catalyst.

Polymerisation catalysts

Polymerisation catalyst

Preparing amidines derived from 6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid

Comptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues

Growing community of inventors

Aramon, France

Jean-Bernard Cazaux