Institut Gustave Roussy

Jean Benard

Anne Chauchereau

Catherine Gaudin

Karim Fizazi

Nader Al Nakouzi

The present invention relates to a prostate cancer cell line CNCM deposit number I-4126, the use thereof for preparing resistant prostate cancer cell lines, the resistant prostate cancer cell lines, and the use of these prostate cancer cell lines for screening compounds of interest.

Prostate cancer cell lines and their use in screening method

The invention concerns a method for preparing an isolated extracellular matrix, secreted by tumor cells, in particular epitheliomatous cells, methods for tumor cell culture using such a matrix, the use of such a matrix for producing a tumor cell line as well as novel tumor cell lines obtained by said method. The invention also concerns a method for selecting a compound capable of inhibiting the growth and/or proliferation of tumor cells, the use of said compounds as medicine for cancer treatment as well as a diagnosis or prognosis method in vitro by chromosomal analysis using said matrices. The invention further concerns a reactor or a kit for cell culture comprising such an extracellular matrix.

Growing community of inventors

L'Hay les Roses, France

Jean Benard