Rhodia Operations

Centre National De La Recherche Scientifique

Universitë De Bordeaux

Université Grenoble Alpes

Commissariat a L'energie Atomique Et Aux Energies

Lternatives Centre National De La Recherche

Scientifique Rhodia Operations

Rhodia Laboratoire Du Futur

Jean-Baptiste Salmon

Mathieu Joanicot

Philippe Laval

Monika Spano

Niels Heinz Junius

Jacques Leng

A microfluidic chip comprising at least one dialysis crystallisation cell. The cell includes: a substrate made of PMMA; a first level including a tank defined at least partially by the substrate and by an outer wall of the cell, the tank being in fluid communication with a channel for inlet and a channel for outlet of a solution allowing the crystallisation method to be implemented; and a second level including a dialysis chamber defined at least partially by an inner wall of the cell without contact with the substrate and by a dialysis membrane forming an interface between the tank and the dialysis chamber, the inner wall including at least one one-piece portion in which the periphery of the membrane is kept sealed.

Microfluidic chip for the crystallisation of molecules, preparation method, device comprising said chip and method for crystallisation of molecules

Fluid flow devices include a small plate (), at least one flow channel () formed into this small plate, at least one storage channel (-) extending from this connection channel, and a set of valves (V-V), each of which is suitable for allowing or stopping the flow of fluid in a corresponding storage channel.

Fluid flow device and assembly employing a temperature gadient for determining at least one characteristic of a physico-chemical system therewith

The crystallization of chemical species/polymorphs comprises forming droplets of a solution of a substance with optionally different concentrations of said substance in an inert phase; producing and storing the droplets in at least one storage microchannel (); forming crystals in all droplets; increasing the temperature in order to induce the dissolution of at least a portion of the crystals in at least some droplets; and analyzing the crystallization and dissolution process.

Crystallization of chemical species/polymorphs and microfluidic apparatus and screening methodology therefor

Growing community of inventors

Bordeaux, France

Jean-Baptiste Salmon