Intron Biotechnology, Inc.

Je Won Park

Yeo Joon Yoon

Jae Kyung Sohng

Sung Ryeol Park

Vectors expressing kanA-kanB-kanK and other kanamycin production-related genes,species recombinant bacteria transformed with the vectors, a method of producing kanamycin antibiotics by the bacteria, and a new kanamycin compound produced by the bacterium are provided. With the use of the recombinant bacteria of the present invention, the direct fermentative biosynthesis of amikacin and tobramycin as semi-synthetic kanamycins is possible, and the yield of kanamycin B as a precursor of the semi-synthetic kanamycin is improved.

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Vectors expressing kanA-kanB-kanK and other kanamycin production-related genes,&#x3c;i/&#x3e; species recombinant bacteria transformed with the vectors, a method of producing kanamycin antibiotics by the bacteria, and a new kanamycin compound produced by the bacterium are provided. With the use of the recombinant bacteria of the present invention, the direct fermentative biosynthesis of amikacin and tobramycin as semi-synthetic kanamycins is possible, and the yield of kanamycin B as a precursor of the semi-synthetic kanamycin is improved.

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Goyang-si, South Korea

Je Won Park