Erina Co., Inc.

Okinawa Research Center Co., Ltd.

Other

University of the Ryukyus

University of the Ryunkyus

Akihisa, Toshihiro

Nagai, Kazuo

Je-Tae Woo

Toshiaki Teruya

Kazuo Nagai

Byung-Yoon Cha

Takayuki Yonezawa

Yuto Teruya

Toshihiro Akihisa

Masato Ohta

Kazumi Yagasaki

Takayuki Yonezama

Shinichi Hasegawa

Kozue Sasaki

Midori Asai

Miki Yamada

Kun-Hyung Lee

Saki Sugiyama

Aki Yamano

Hiroyuki Akazawa

Kosuke Sueyoshi

Ayaka Hibino

The object is to provide a method of manufacturing a fraction containing nobiletin and tangeretin at high concentrations, which is excellent in terms of safety, economic efficiency, and the potential for industrialization. The method includes (1-1) a step of treating citrus fruit with hot water to obtain a hot water-treated product; (1-2) a step of drying the hot water-treated product to obtain a dried product; (1-3) a step of treating the dried product with a solvent capable of dissolving nobiletin and tangeretin to obtain a nobiletin and tangeretin solution; (3) a step of concentrating and/or drying the nobiletin and tangeretin solution to obtain a nobiletin and tangeretin concentrate; and (4) a step of treating the nobiletin and tangeretin concentrate with a dilute alkali to obtain a composition containing nobiletin and tangeretin as an insoluble component, and by a composition containing nobiletin and tangeretin at high concentrations manufactured by the method.

Method for manufacturing composition containing nobiletin and tangeretin derived from citrus fruits, and composition containing nobiletin and tangeretin obtained thereby

An objective of the present invention is to provide a method for producing a nepodin-containing extract containing a high concentration of nepodin with less contaminants present therein thereby being able to be readily carried out on an industrial scale, when compared to the conventional techniques. The objective is solved by A method for producing a nepodin-containingplant extract, the method comprising the following steps (1) to (5): (1) a step of subjecting aplant to an extraction treatment using a nepodin-dissolving solvent to obtain a crudeplant extract; (2) a step of subjecting the crudeplant extract to a water-adding treatment and/or concentration treatment to obtain a solid crudeplant extract; (3) a step of subjecting the solid crudeplant extract to a weak alkali treatment to obtain a weak alkali insoluble product; (4) a step of subjecting the weak alkali insoluble product to a strong alkali treatment to obtain a strong alkali soluble product; and (5) a step of subjecting the strong alkali soluble product to a neutralization treatment to obtain the nepodin-containingplant extract.

Method of producing high-nepodin-containing rumex plant extract and high-nepodin-containing rumex plant extract

The present invention provides a highly safe pharmaceutical composition for preventing and/or treating bone disease, a pharmaceutical preparation comprising thereof, a health food comprising thereof, a functional food comprising thereof. Since the present invention comprises the arylheptanoid compound shown in the following formula (I) and the derivatives thereof, it enables to prevent and/or treat the bone disease. (In the formula (I), Rand Rare a functional group selected from the group consisting of a hydrogen atom, alkyl group having carbon numbers 1 to 3, monosaccharide and disaccharide; R, R, and Rare a functional group selected from the group consisting of a hydrogen atom, an oxygen atom, alkyl group having carbon numbers 1 to 3, monosaccharide and disaccharide; Rmay be bound on meta-position against heptylene group of another aryl group to form a ring.)

Pharmaceutical composition for preventing and/or treating bone disease, functional food or health food and pharmaceutical preparation comprising thereof as active ingredient

Agents or pharmaceutical compositions for promoting osteoblast differentiation include purified auraptene or coumarin analogs thereof represented by the following formula 1: wherein R1 represents a hydrogen, a hydroxy, a methoxy, a methyl, an ethyl, a propyl, a carboxyl, a carboxymethyl, or a carboxyethyl; R2 represents a hydrogen, a hydroxy, a methoxy, a methyl, an ethyl, a propyl, a carboxyl, a carboxymethyl, a carboxyethyl or a coumarinyl; R3 represents a hydrogen, a hydroxy, a methoxy, a methyl, an ethyl, a propyl, a carboxyl, a carboxymethyl or a carboxyethyl; and R4 represents a hydrogen, a C-Cliner or branched alkyl, an alkenyl, an alkadienyl or an alkatrienyl.

Agent for promoting osteoblast differentiation, pharmaceutical composition for promoting bone formation, and food for special dietary use containing auraptene analog as active ingredient

The purpose of the present invention is to provide a highly safe composition that improves glucose tolerance and sugar metabolism at skeletal muscles, and a prevention/treatment drug for diabetes/metabolic syndrome containing the composition. Provided is a composition that is for improving sugar metabolism and glucose tolerance and that contains a compound represented by formula (I) derived from a plant selected from the group consisting of, andas the active ingredient.

Sugar metabolism improving composition, and pharmaceutical preparation containing said composition

The present invention provides the pharmaceutical compositions, the pharmaceutical preparations thereof as an active ingredient, the health food, the food with health-promoting benefits and the like. The present invention provides the above-mentioned pharmaceutical preparations and the like comprising at least one of the compound shown in the following formula (I), physiologically acceptable salt thereof, or hydrate thereof. (wherein, R', R&#x2032;, and R&#x2032;are independently a hydrogen atom, OH, or alkoxy group having C1 to C3, respectively. R, R, and Rare independently a hydrogen atom or alkenyl group having C3 to C5, respectively).

Composition for preventing and/or treating bone disease, physiologically functional or health food containing thereof, and pharmaceutical containing thereof as active ingredients

Growing community of inventors

Tokyo, Japan

Je-Tae Woo