Industry-University Cooperation Foundation Hanyang University

Forhumantech Co., Ltd.

Iucf-Hyu

Je-Min Choi

Sangho Lim

Do-Hyun Kim

Ja-Hyun Koo

Wonju Kim

Sang-Kyou Lee

Jiyun Kim

Seung-Kyou Lee

Hyun-Jung Cho

Jahyun Koo

Jung Ah Lee

Hong Gyun Lee

The present disclosure relates to a fusion protein including a cell-penetrating peptide and an LRR domain derived from the NLRX1 protein. Since the fusion protein can effectively inhibit and alleviate the disease severity of autoimmune diseases and directly regulates T cell functions, it can be usefully used to treat or prevent autoimmune diseases.

Composition for preventing or treating autoimmune disease based on LRR domain of NLRX1 protein

The present invention relates to pharmaceutical compositions for preventing or treating pulmonary metastasis of cancer. More specifically, the present invention relates to compositions that enhance anti-cancer immunity of the lung rather than induce death of advanced cancer, thus being effective in inhibiting, preventing or treating pulmonary metastasis of cancer.

Pharmaceutical compositions for preventing or treating pulmonary metastasis of cancer including CHI3L1 inhibitor as active ingredient

The composition of the present invention can inhibit homologous human T cell reaction and the phenomenon of infiltration which reduces skin graft damage in vivo, thereby enabling prompt, rapid and effective graft rejection prevention or treatment effects at a low concentration. In addition, the present invention has advantages of successfully controlling in vivo human T cell reactions, as compared with conventional therapeutic agents, thus providing few side effects, the possibilities of local high-dose administration of therapeutic agents and potentially new treatments and prescriptions.

Pharmaceutical composition for preventing and treating transplant rejection

The present invention has a function of enabling the penetration of the blood-brain barrier and the blood-spinal cord barrier of the central nervous system, which have not been significantly penetrated, with excellent efficiency, thereby enabling a rapid, quick, and more efficient therapeutic effect to be obtained through low dose administration. In addition, the present invention enables local administration unlike conventional therapeutic agents, thereby decreasing side effects, and enables local administration of a therapeutic agent at a high concentration, thereby enabling potentially new treatments and prescriptions.

Peptides having effects of preventing or treating central nervous system diseases and pharmaceutical compositions for preventing or treating central nervous system diseases containing same as active ingredient

The present disclosure is directed to providing a new skin-penetrating peptide, a fusion product with a biologically active substance bound using the same, a cosmetic composition containing the same and a pharmaceutical composition for external application to skin containing the same. The skin-penetrating peptide of the present disclosure is less likely to cause an immune response as compared to existing skin-penetrating peptides and exhibits remarkably improved skin permeability. Therefore, the biologically active substance can be effectively delivered through the skin, particularly through the stratum corneum.

Skin-penetrating peptide and method for using same

The present disclosure is directed to providing: a new cell-penetrating peptide; and a composition for delivering a biologically active substance, a composition for gene therapy, a method for delivering a biologically active substance and a method for gene therapy using the same. The cell-penetrating peptide of the present disclosure can effectively deliver a protein into human cells and tissues, can deliver a protein with higher efficiency in comparison with a TAT peptide that is commercially used as a cell-penetrating peptide, and can also be usefully used in delivering a biologically active substance such as a protein, a genetic material, a chemical compound, etc. which may be used for a therapeutic purpose into cells.

Cell penetrating peptide and method for delivering biologically active substance using same

The present invention relates to methods for delivery of fusion polypeptides into cells. Methods are provided for local delivery of fusion polypeptides, e.g., through the skin, eye and the airway, to prevent allergic inflammation, airway hyper-responsiveness and to block T cell activation. Methods for delivery of fusion polypeptides to suppress graft rejection are also provided.

Growing community of inventors

Seoul, South Korea

Je-Min Choi