Institute for Environmental Health, Inc.

Fluidigm Corporation

Helicos Biosciences Corporation

Sample6 Technologies, Inc.

Phage Diagnostics, Inc.

Jayson Linn Bowers

Michael Koeris

Daniel Robert Brownell

Robert Patrick Shivers

Edyta Krzymanska-Olejnik

J William Efcavitch

Subramanian Marappan

Jason Wyatt Holder

Suhaib Siddiqi

Judith Mitchell

Michael Cappillino

Atanu Roy

Philip Richard Buzby

Xiaopeng Bai

Mirna Jarosz

Timothy Kuan Ta Lu

Julie Thomason

Mirna Jaroza

Methods of detecting target bacteria are provided. In some embodiments, the methods comprise exposing a sample to a phage capable of infecting target bacteria, said phage comprising a heterologous nucleic acid sequence encoding a marker. In some embodiments, the target bacteria comprise. In some embodiments, the target bacteria are all. Recombinantphage comprising a heterologous nucleic acid sequence encoding a marker are also provided as are useful combinations of such phage and articles of manufacture comprising such phage, among other things.

Recombinant phage for listeria detection

Composition and methods for the detection of one or more target microbe(s) are provided. Compositions of the disclosure include at least one recombinant phage capable of infecting a target microbe, said phage comprising at least a capsid protein sequence, a ribosome binding site, and a codon-optimized marker. Compositions of the disclosure may further include an aqueous solution that enhances the ability to detect marker expression upon phage infection of the target microbe. In some embodiments the target microbe include is

Codon optimized recombinant phage and methods of using same

Methods of detecting target bacteria are provided. In some embodiments the methods comprise exposing the sample to a phage capable of infecting a set of target bacteria and comprising a heterologous nucleic acid sequence encoding a marker. In some embodiments the target bacteria comprise. In some embodiments the target bacteria are all. Recombinantphage comprising a heterologous nucleic acid sequence encoding a marker are also provided as are useful combinations of such phage and articles of manufacture comprising such phage, among other things.

Phage-based bacterial detection assay

Methods of making recombinant phage, compositions and articles of manufacture of same for bacterial detection

The invention generally relates to nucleotide analogs and methods of their use in sequencing-by-synthesis reactions. In certain embodiments, the invention provides a nucleotide analog including a detectable label attached to a nitrogenous base portion of a nucleotide analog by a cleavable linker, in which contact of the analog with at least one activating agent results in cleavage of the label and elimination of the linker, thereby producing a natural nucleotide, a 9-deaza-G, 9-deaza-A, or &#x3c8;-uridine.

Nucleotide analogs

The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.

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Cambridge, MA, United States of America

Jayson Linn Bowers