US Government As Represented by the Secretary of the Army

Albert Einstein College of Medicine

University of Toronto

Jayne F Koellhoffer

Sachdev Singh Sidhu

Kartik Chandran

Jonathan R Lai

Julia Frei

John M Dye

Gang Chen

Samantha Zak

The present invention addresses a need for antibodies useful for filovirus infections.

Filovirus antibody

The present invention addresses a need for improved treatments for filovirus infections. This invention provides an isolated humanized anti-filovirus glycoprotein pre-fusion core antibody comprising a framework region having a sequence of 95% or greater identity to a human antibody framework region. Also provided is a method of treating and/or inhibiting a filovirus infection in a subject comprising administering to the subject an amount of any of the antibodies described herein, or an amount of an antigen-binding fragment thereof. Also provided is composition comprising any of the antibodies described herein, or or an amount of an antigen-binding fragment thereof. In an embodiment, the composition comprises a pharmaceutically acceptably carrier.

Therapy for filovirus infection

The present invention addresses a need for improved treatments for filovirus infections.

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New York, NY, United States of America

Jayne F Koellhoffer