Yale University

Jaymin Patel

Farren J Isaacs

Jason Crawford

Tyler Goddard

Ryan Gallagher

Hyun Bong Park

Alexis Rovner

Provided herein are novel antibacterial compounds of Formula I. The compounds can be made through enzymatic oxidative dimerization in the presence of a suitable organism and one or more metal salts. Pathogenic bacteria exposed to the compound of Formula I do not develop resistance to these compounds even after prolonged exposure. Also provided herein are methods of treating bacterial infections, and method of killing or disinfecting bacteria.

Anti-bacterial stilbene derivatives and methods of use

Methods and strategies for introducing genetic safeguards into microorganisms, genetically modified organisms (GMO) including the safeguards, and methods of use thereof are provided. The genetic safeguards generally impart a low escape frequency, are robust, and are modular. Safeguards with low escape frequency prevent the rise of mutants escaping defined media and limit growth in the wild. Robust safeguards retain wild-type levels of fitness while also maintaining containment in diverse growth conditions.

Compositions and methods for biocontainment of microorganisms

Growing community of inventors

New Haven, CT, United States of America

Jaymin Patel