Motorola Corporation

Jaymie Robin Sawyer

Changming Li

George N Maracas

Peiming Zhang

Barbara M Foley

Vi-En Choong

Cynthia G Briscoe

The present invention provides an apparatus and methods for the electrical detection of molecular interactions between a probe molecule and a protein or peptide target molecule, but without requiring the use of electrochemical or other reporters to obtain measurable signals. The methods can be used for electrical detection of molecular interactions between probe molecules bound to defined regions of an array and protein or peptide target molecules which are permitted to interact with the probe molecules.

Protein and peptide sensors using electrical detection methods

A capillary electrophoresis device having a substrate layer and a cover layer, with a plurality of electrophoresis channels formed in the substrate layer, includes an optical waveguide system that transmits excitation radiation from a source port into each one of the electrophoresis channels. The optical waveguide system is defined by regions, within either the cover or substrate, that have an index of refraction higher than that of the surrounding material.

Capillary electrophoresis devices incorporating optical waveguides

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Chandler, AZ, United States of America

Jaymie Robin Sawyer