Ortho-mcneil Pharmaceutical Corp.

Ortho Pharmaceutical Corporation

Jayashree Pyati

Mark G Erlander

Timothy W Lovenberg

Arne Huvar

Adrienne Dubin

Rene Huvar

Jessica Y Zhu

Jose E Galindo

DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.

Methods of use of DNA encoding a human histamine receptor of the H3 subtype

Human histamine receptor of the H3 subtype

Method of identifying compounds that modulate human histamine H3 receptor

DNA encoding human acid sensing ion channel BnaC4 has been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.

DNA encoding human acid-sensing ion channel BNaC4 (ASIC4)

DNA encoding a human histamine receptor of the H3 subtype

A DNA molecule encoding a novel isoform of the human T-type low voltage activated calcium channel (alpha1G-c) has been cloned and characterized. The biological and structural properties of this protein is disclosed, as is the amino acid and nucleotide sequence.

DNA encoding human alpha1G-C T-Type calcium channel

DNA encoding as human histamine receptor of the H3 subtype

Growing community of inventors

San Diego, CA, United States of America

Jayashree Pyati