Pfizer Corporation

Jayasankar Jasti

Robert L Dow

David W Piotrowski

Ariamala Gopalsamy

David Hepworth

Ralph Pelton Robinson, Jr

Shawn Cabral

Mihir D Parikh

Chulho Choi

Arjun Venkat Narayanan

Hatice Gizem Yayla

Ming Zhu Chen

Olugbeminiyi Omezia Fadeyi

Lee Richard Roberts

Lyn Howard Jones

Agustin Casimiro-Garcia

Agustin Casimiro Garcia

The invention relates to pyrazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to HbS modulators of formula (I) HbS modulators are potentially useful in the treatment of a wide range of disorders, including sickle cell disease (SCD).

Chemical compounds

The invention relates to pyrazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to HbS modulators of formula (I) or tautomers thereof, or pharmaceutically acceptable salts of said modulators or tautomers thereof, wherein X, Y, Rand Rare as defined in the description. HbS modulators are potentially useful in the treatment of a wide range of disorders, including sickle cell disease (SCD).

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East Lyme, CT, United States of America

Jayasankar Jasti