Carl Zeiss Gmbh

Optovue, Inc.

Carl Zeiss Meditec Gmbh

Carl Zeiss Ophthalmic Systems, Inc.

Carl Zeigs Medike, Inc.

Carl Zeiss Meditec Ag

Jay Wei

Ben Jang

Thomas Hellmuth

Ming Lai

Tony H Ko

Yonghua Zhao

David E Huang

Jing-Gang Xie

Yi-Sing Hsiao

Qienyuan Zhou

Richard Rosen

Christopher J R V Baker

James Foley

Michael Hee

Jianping Wei

Charles E Campbell

Scott A Meyer

Utkarsh Sharma

Shiyu Zhang

Alan R Kirschbaum

Christopher L Petersen

Christopher T Wing

Jochen Horn

Kabir Arianta

Zheng-wu Li

Manish D Kulkarni

Shuw-Shenn Luh

Ning Y Chan

Matt J Everett

Markus Kohnle

Yuanmu Deng

Seema Somani

Dragos Stanescu

Tao Huang

Jing Cui

David Huang

Optical Coherence Tomography Angiography (OCTA) image representation is obtained having OCTA pixels assigned respective OCTA values. A vessel density map is computed from the OCTA image representation. A fractional deviation map and/or a pattern deviation map is computed for the patient from the vessel density map and a normative database, wherein: (1) the fractional deviation map represents a percent loss of vessel density at each pixel location relative to an expected value based on the normative database; and (2) computing the pattern deviation map includes: computing a pattern map of the vessel density representing a normalized vessel density pattern of the vessel density map relative to an average value of the vessel density map; and computing the pattern deviation map using the pattern map. A loss is determined by using at least one of the fractional deviation map and the pattern deviation map. Other features are also provided.

Methods and apparatus for retina blood vessel assessment with OCT angiography

A method of processing a 3D OCT dataset is present. A method according to some embodiments of the present invention includes obtaining an OCT data from the 3D OCT dataset; obtaining an OCTA data from the 3D OCT dataset; performing segmentation for at least one boundary on the OCT data; processing the OCTA data in a region of interest to create at least one image representation by assigning a value to each pixel of each of the image representation; and displaying at least one image representation.

In some embodiments of the present invention, a method of reducing artifacts includes obtaining OCT/OCTA data from an OCT/OCTA imager; preprocessing OCTA/OCT volume data; extracting features from the preprocessed OCTA/OCT volume data; classifying the OCTA/OCT volume data to provide a probability determination data; determining a percentage data from the probability data determination; and reducing artifacts in response to the percentage data.

Methods and apparatus for reducing artifacts in OCT angiography using machine learning techniques

Embodiments of automatically aligning imager are presented. In accordance with some embodiments, an imaging system includes an adjustment stage; an auto-alignment optics mounted on the adjustment stage and coupled to image an object, the auto-alignment optics including at least one video camera providing an image of the object; imaging scanning optics mounted on the adjustment stage and coupled to scan the object; an imager coupled to the imaging scanning optics; and a processor coupled to the adjustment stage and the auto-alignment optics, the processor executing instructions to receive the image of the object and adjust the adjustment stage to align the optics with the imaging scanning optics.

Automatic alignment of an imager

An optical coherence tomography system is provided. The system includes an OCT imager; a two-dimensional transverse scanner coupled to the OCT imager, the two-dimensional transverse scanner receiving light from the light source and coupling reflected light from a sample into the OCT imager; a computer coupled to receive 3D OCT data from the OCT imager, the computer further processes the 3D OCT data; wherein the processing the 3D OCT data includes: correcting motion artifacts in baseline mode; generating reference data in baseline mode; performing segmentation to identify volumes of interest; extracting feature information, the feature information including reflectivity, texture, or the combination thereof.

Motion correction and normalization of features in optical coherence tomography

An imaging method according to some embodiments of the present invention includes obtaining working distance information from an optical coherence tomography system, the working distance being the working distance to the sample; obtaining information from one or more ocular systems; combining the information from said optical coherence tomography information and said ocular system; and displaying said combined information.

Method and apparatus for enhanced eye measurements

An imaging method is disclosed. An imaging method according to some embodiments can include obtaining a plurality of measurements of an eye for at least one location by scanning optical radiation across the eye; determining a preferred measurement axis from the plurality of measurements; and processing the plurality of measurements to obtain information of the eye.

Enhanced biometry using optical coherence tomography

In accordance with some embodiments, a method of eye examination includes acquiring OCT data with a scan pattern centered on an eye cornea that includes n radial scans repeated r times, c circular scans repeated r times, and n* raster scans where the scan pattern is repeated m times, where each scan includes a A-scans, and where n is an integer that is 0 or greater, r is an integer that is 1 or greater, c is an integer that is 0 or greater, n* is an integer that is 0 or greater, m is an integer that is 1 or greater, and a is an integer greater than 1, the values of n, r, c, n*, and m being chosen to provide OCT data for a target measurement, and processing the OCT data to obtain the target measurement.

Scanning and processing using optical coherence tomography

A method is disclosed for use in eye registrations and examinations, some embodiments of the method including acquiring scan pattern scans; forming images from the scans; registering the images; generating a feature map from the scan pattern scans; identifying features on the feature map; and recording positional information of features.

Method of eye registration for optical coherence tomography

A method of performing an OCT image scan is presented. Other images are taken and a template is formed to correct the OCT images, for example, for eye motion, blood vessel placement, and center offset. In some embodiments, video images are taken simultaneously with the OCT images and utilized to correct the OCT images. In some embodiments, a template OCT image is formed prior to acquisition of the OCT images and the template OCT image is utilized as a template from which to correct all of the OCT images.

Method of eye examination by optical coherence tomography

An eye examination system is presented that obtains several parameters of the eye. A system according to some embodiments of the present invention include a keratometry system, a low coherence reflectometry system, and a low coherence interferometry system co-coupled to the eye. In some embodiments, the low coherence interferometry system can provide interferometric tomography data. A processor can be coupled to receive data from the keratometry system, the low coherence reflectometry system, and the low coherence interferometry system and calculate at least one parameter of the eye from that data.

Optical apparatus and methods for performing eye examinations

A Fourier-domain optical coherence tomography (OCT) imager is presented. An OCT imager according to the present invention can have an auto-alignment process. The auto-alignment process automatically adjusts at least one optical component of a spectrometer of the imager so that the spectrometer is aligned during an imaging session. In addition to the auto-alignment process, OCT spectra are normalized for background spectra and for noise characteristics in order to provide a more accurate and clear OCT image.

Fourier-domain optical coherence tomography imager

In accordance with the present invention, embodiments of interferometers are presented that improves both the polarization dependency problem and helps prevents light from being reflected back into the light source, among other things. Interferometer embodiments can include an isolator coupled to a light source and polarization dependent optics coupled with the isolator to provide light to a reference arm and a sample arm, wherein reflected light provided to optical detectors is such that a polarization independent optical signal can be formed in an optical signal processor coupled to the optical detectors, and the isolator blocks reflected light from the reference arm and the sample arm from entering the light source. In some embodiments, a balanced detection system can be utilized to reduce noise.

High efficiency low coherence interferometry

An eye examination instrument is presented that can perform multiple eye tests. The instrument includes an illumination optical path and an imaging optical path, wherein a focus element in the illumination optical path is mechanically coupled to a focus element in the imaging optical path. In some embodiments, the eye examination instrument can perform a visual eye test, a fundus imaging test, and an optical coherence tomography test.

Optical apparatus and method for comprehensive eye diagnosis

One embodiment of the present invention is a scanner for a beam of scanning optical coherence tomography (&ldquo;OCT&rdquo;) radiation that includes: (a) a source of OCT radiation; (b) a scanner; and (c) scanning optics whose image surface has a negative field curvature.

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Fremont, CA, United States of America

Jay Wei