Abbott Laboratories Corporation

Pharmacia Corporation

G.d. Searle LLC

Jay S Trivedi

Samuel J Tremont

Mark John Pozzo

Jon P Lawson

Claire A Przybyla

Kevin J Koeller

James C Peterson

Payman N Farid

Pierre-Jean Colson

Kevin Babiak

Grace Mary Wagner

Benxin Zhi

Robert Hett

Andrew Carpenter

Eduardo K Mar

Vladislav Orlovski

Lawrence M Miller

Shine Chou

Christian H Huber

Gerald A Weisenburger

James J Li

Steven L Krill

Yihong Qiu

Sharon L Graham

Kolette M Flood

James Li

Among its several embodiments, the present invention provides an improved process for the preparation of tetrahydrobenzothiepine-1,1-dioxide compounds; the provision of a process for preparing a diastereomeric mixture of tetrahydrobenzothiepine-1,1-dioxide compounds from a single diastereomer of such compounds; the provision of a process for the preparation of 3-bromo-2-substituted propionaldehyde compounds; and the provision of a process for the preparation of 3-thio-2-substituted propionaldehyde compounds.

Method for the preparation of tetrahydrobenzothiepines

The present invention provides a tablet for the controlled release of an active agent comprising (a) a matrix layer comprising an active agent embedded in a non-swelling, non-gelling hydrophobic matrix; (b) a first barrier layer laminated to a single face of the matrix layer; and (c) an optional second barrier layer laminated to the opposite face of the matrix layer and oppositely disposed to the first barrier layer; wherein the matrix comprises up to about 80% active agent and from about 5% to about 80% by weight of nonswellable waxes or polymeric material insoluble in aqueous medium, and the first and second barrier layers independently comprise (1) polymeric material exhibiting a high degree of swelling and gelling in aqueous medium or (2) nonswellable wax or polymeric material insoluble in aqueous medium.

Tablet for the controlled release of active agents

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Skokie, IL, United States of America

Jay S Trivedi