Seahorse Bioscience

Flir Systems Boston, Inc.

Seahorse Biosciences

Agilent Technologies, Inc.

Jay S Teich

Andy C Neilson

Paul McGarr

Michael R Sweeney

Geoff Uhl

Jason Dell'Arciprete

Suzanne Armitstead

Sarah Burroughs

Jim Orrell

Stephen C Young

Stephen G Young

Devices and methods that measure one or more properties of a living cell culture that is contained in liquid media within a vessel, and typically analyzes plural cell cultures contained in plural vessels such as the wells of a multiwell microplate substantially in parallel. The devices incorporate a sensor that remains in equilibrium with, e.g., remains submerged within, the liquid cell media during the performance of a measurement and during addition of one or more cell affecting fluids such as solutions of potential drug compounds.

Cell analysis apparatus and method

A multiwell microplate for holding liquid samples, and a method of use thereof. The multiwell microplate includes a frame defining a plurality of wells disposed in a single column, each well having an opening with a length l. A moat is disposed about the plurality of wells. A plurality of walls traverses the moat, the walls defining a plurality of compartments, each compartment having a length lselected from a range of greater than land less than 6l. A multiwell microplate carrier includes a body defining a plurality of regions configured to hold a plurality of multiwell microplates in parallel, each multiwell microplate defining a single column of wells, and each of the regions defining a plurality of openings that are adapted to mate with the single columns of wells.

Single column microplate system and carrier for analysis of biological samples

An apparatus including a plurality of wells for conducting analysis of three-dimensional cell samples (e.g., tissue samples) and methods for experimenting with a three-dimensional sample. A removable insert for use with the apparatus enables plunger-driven perfusion of the three-dimensional sample.

Apparatus and methods for three-dimensional tissue measurements based on controlled media flow

A method of analyzing cells disposed in media within a vessel includes the steps of providing a vessel having an original volume of media about the cells, reducing the original volume of media about at least a portion of the cells to define a reduced volume of media, and analyzing a constituent related to the cells within the reduced volume of media. An apparatus for analyzing cells includes a stage adapted to receive a vessel holding cells and a volume of media, a plunger adapted to receive a barrier to create a reduced volume of media within the vessel including at least a portion of the cells, the barrier adapted for insertion into the vessel by relative movement of the stage and the plunger, and a sensor in sensing communication with the reduced volume of media, wherein the sensor is configured to analyze a constituent disposed within the reduced volume.

Method and device for measuring multiple physiological properties of cells

Cartridge

Microplate assembly

Carrier

Microplate

Apparatus and methods for performing calorimetry. The apparatus include optical devices for detecting thermal processes and multiwell sample plates for supporting samples for use with such optical devices. The methods include measurement strategies and data processing techniques for reducing noise in measurements of thermal processes. The apparatus and methods may be particularly suitable for extracting thermal data from small differential measurements made using an infrared camera and for monitoring chemical and physiological processes.

Apparatus and methods for infrared calorimetric measurements

Growing community of inventors

Berlin, MA, United States of America

Jay S Teich