Other

Korea Institute of Science and Technology

K2b Therapeutics, Inc.

Jay S Kim

Sun Hwa Kim

Ick Chan Kwon

Hong Yeol Yoon

Yoo Soo Yang

Jong Won Lee

In-San Kim

HoWon J Kim

Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a target cell are described. The therapeutic compounds are configured to bind CD47 on the surface of a red blood cell and to be subsequently transferred to CD47 on the surface of the target cell, the therapeutic compound ultimately being internalized by the target cell via endocytosis. The target cell may be a cancer cell.

Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a target cell

Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a target cell are described. The therapeutic compounds are configured to bind CD47 on the surface of a red blood cell and to be subsequently transferred to CD47 on the surface of the target cell, the therapeutic compound ultimately being internalized by the target cell via endocytosis. The target cell may be a fibrotic cell.

The device includes a set of rotatable vanes and a set of stationary vanes which are mounted within a cylindrical housing. The set of rotatable vanes are connected to a post located at the axis of the housing and rotate relative to the post in response to the intake or exhaust fluid impinging on the vanes which are angled relative to the direction of flow of the fluid stream. The set of stationary vanes are rigidly secured to the post and also rigidly secured to the housing walls. The set of stationary vanes are positioned adjacent the set of rotatable vanes and are similarly angled relative to the direction of flow of the fluid stream in order to deflect the fluid stream and impart a swirling motion to the fluid stream in order to provide more complete mixing of the air/fuel mixture of the intake fluid stream or scavenging of the exhaust fluid stream. Tabs which extend radially outwardly from the housing ends secure the device within an intake or exhaust passageway.

Fluid swirling device having rotatable vanes

The device includes a pair of flat planar vanes securely mounted within a cylindrical housing. The vanes have a medial slit extending from the center to a longitudinal end of the vane. The vanes are interconnected at the slits so that they are in criss-cross positioning. The vanes are axially angled so that when positioned in an intake air duct the vanes impart a swirling motion to the air entering the engine providing more complete mixing of the air and fuel and when positioned in an exhaust passageway the vanes impart a swirling motion to the exhaust gases exiting the engine providing scavenging of the exhaust gases.

Fluid swirling device

The device is utilized to provide swirling of either intake air flow or exhaust gas flow of an internal combustion engine. When used to swirl intake fluid flow, the device is positioned in the intake passageway for air entering the carburetor or fuel injection subsystem. The swirling of the air provides more complete mixing of the air and fuel entering the combustion chamber of the engine thereby providing more complete combustion of the fuel mixture. When utilized to swirl exhaust fluid flow, the device is positioned in the exhaust passageway for exhaust gases exiting the exhaust manifold. The swirling of the exhaust gases minimizes slowing of exhaust gas flow through the exhaust system to reduce back pressure and thereby provide more complete combustion. The device includes a set of flat planar vanes which are mounted within a housing. The varies are angled to impart a swirling motion to the intake air or exhaust gas passing through the housing. The vanes are also provided with curved trailing edges to minimize impediment to fluid flow passing through the housing and provided with angled trailing end portions to enhance effectiveness of the vanes in imparting a swirling motion to the fluid flow.

Fluid swirling device for an internal combustion engine

Engine intake port swirl vanes

The device is utilized to create swirling, turbulent flow to the air entering an internal combustion engine, and to the exhaust gases therefrom prior to the gases entering an air pollution system. The device utilizes multiple curved and radially angled vanes to force the air into a predetermined turbulent, swirling pattern. For carbureted engines, the device is positioned between the air filter and the inlet to the carburetor and on fuel injection engines, the device is positioned at the inlet port of the intake manifold. 100% of the air which will enter the engine will have been forced into a swirling and turbulent flow by the device for maximum combustion efficiency. Within the exhaust system, the device is positioned within the exhaust tube(s) just upstream of the catalytic converter to force the gases into a swirling and turbulent flow, thereby permitting a more efficient utilization of the catalytic converter process.

Growing community of inventors

Santa Fe Springs, CA, United States of America

Jay S Kim