Schering Corporation

Pharmacopeia Drug Discovery, Inc.

Merck Sharp + Dohme Corp.

Pharmacopeia Inc.

Jay S Fine

Arthur G Taveras

Younong Yu

Purakkattle J Biju

Jianhua Chao

Daniel Lundell

Loretta A Bober

John J Baldwin

Ge Li

Michael P Dwyer

Daniel M Solomon

Margaret H Sherlock

Junying Zheng

Tony Priestley

James P Jakway

Michael J Grace

Jianping Chao

William Kreutner

J Robert Merritt

Cynthia J Aki

Gaifa Lai

Johan A Ferreira

Bernd Kaiser

Richard W Bond

Minglang Wu

Laura L Rokosz

Kingsley H Nelson, Jr

Evan A Hecker

Eric McFee Parker

Motasim Billah

Angelo Reggiani

James Jakway

Methods of treating chemokine-mediated diseases are disclosed. The methods comprise the administration of CXC-Chemokine receptor antagonists of the formula or pharmaceutically acceptable salts or solvates thereof, in combination with other classes of pharmaceutical compounds. The chemokine-mediated diseases include acute and chronic inflammatory disorders, psoriasis, cystic fibrosis, asthma and cancer. Also disclosed are novel compounds of formula (I).

Treatment of chemokine mediated diseases

The present invention provides methods for treating demyelination and associated conditions by administering at least one sterol absorption inhibitor and compositions, therapeutic combinations and methods including: (a) at least one sterol absorption inhibitor; and (b) at least one demyelination treatment which can be useful for preventing or treating demyelination and associated conditions, such as multiple sclerosis.

Methods and therapeutic combinations for the treatment of demyelination

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

Compounds of formula ##STR1## or pharmaceutically acceptable salts thereof, wherein E, Q, T, U, V, L, Z, X, W, M, Y and Y' are as set forth herein, are described. These compounds are useful as agents in the treatment of allergy, inflammation, autoimmune diseases, B-cell lymphomas, tumors, and the after effects of bone marrow transplantation.

Naphthyridines which affect IL-4 and G-CSF

A method for enhancing the immune response of a mammal to a vaccine comprising administering to such a mammal an effective amount of IL-10 in conjunction with the vaccine. A pharmaceutical composition comprised of an effective amount of IL-10, a natural, synthetic or recombinant antigen and a pharmaceutcally acceptable carrier.

Method for enhancing the antibody response to specific antigens with

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Bloomfield, NJ, United States of America

Jay S Fine