Gilead Sciences, Inc.

Gilead Pharmasset LLC

Other

Jay P Parrish

Richard L Mackman

Dustin S Siegel

Hon Chung Hui

Choung U Kim

Aesop Cho

Oliver L Saunders

David Sperandio

John O Link

James G Taylor

Michael L Mitchell

Darryl Kato

Thorsten A Kirschberg

Adrian S Ray

Hongyan Guo

Michael Sangi

Hai Yang

William John Watkins

Manoj C Desai

Jeromy J Cottell

Scott E Lazerwith

Elizabeth M Bacon

Lianhong Xu

Randall Halcomb

Winston C Tse

Eda Y Canales

Hongtao Liu

Jianyu Sun

Evan S Krygowski

Michael Graupe

Hyung-Jung Pyun

Qi Liu

Randall W Vivian

Robert Jordan

Edward Doerffler

Lijun Zhang

Chandrasekar Venkataramani

Zheng-Yu Yang

Scott D Schroeder

Constantine G Boojamra

Thomas Butler

Michael O'Neil Hanrahan Clarke

Barton W Phillips

James Ming Chen

Petr Jansa

Haolun Jin

Samuel E Metobo

Ryan McFadden

James D Trenkle

Joseph H Saugier

Byoung Kwon Chun

Kerim Babaoglu

Eugene J Eisenberg

Dorothy Agnes Theodore

Dustin Siegel

Michael O' Neil Hanrahan Clarke

Michael R Mish

Jie Xu

Alan X Huang

Chien-Hung Chou

Jason K Perry

Ding Xue

Hyung-Jun Pyun

Terry Kellar

Michael O'neil Clarke

Ryan Mcfadden

Neil Squires

Xiaoning Sheng

James Taylor

Randall L Halcomb

Richard Mackman

Michael O'neil Hanrahan Clarke

Hongtae Liu

Thorstens A Kirschberg

Chuong U Kim

Clarke; Michael O'Neil Hanrahan Hanrahan

Saugier; Joseph H H

Schroeder; Scott D D

Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein the 1' position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections.

Methods and compounds for treatingvirus infections

Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

Methods for treatingvirus infections

Methods and compounds for treating paramyxoviridae virus infections

Methods for treating filoviridae virus infections

Methods for treating Filoviridae virus infections

Compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections are provided. The compounds and compositions are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

Compounds and methods for antiviral treatment

Methods and compounds for treating Paramyxoviridae virus infections

The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Antiviral compounds

The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

Pyrazolo[1,5-A]pyrimidines for antiviral treatment

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Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 1' position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

1'-substituted carba-nucleoside analogs for antiviral treatment

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Redwood City, CA, United States of America

Jay P Parrish