University of Washington

The Medical College of Wisconsin, Inc.

Adverum Biotechnologies, Inc.

University of Florida Research Foundation, Incorporated

Jay Neitz

Maureen Neitz

James A Kuchenbecker

Thomas W Chalberg, Jr

William W Hauswirth

Thomas W Chalberg

Sara S Patterson

Alexandra Neitz

Certain embodiments of the present invention are directed to therapeutic intervention in patients with eye-length-related disorders to prevent, ameliorate, or reverse the effects of the eye-length-related disorders. Embodiments of the present invention include methods for early recognition of patients with eye-length-related disorders, therapeutic methods for inhibiting further degradation of vision in patients with eye-length-related disorders, reversing, when possible, eye-length-related disorders, and preventing eye-length-related disorders. Additional embodiments of the present invention are directed to particular devices used in therapeutic intervention in patients with eye-length-related disorders.

Method and apparatus for limiting growth of eye length

Lighting devices, systems, and methods for selectively activating S cones and L+M cones in a human retina and for regulating the phase of circadian rhythm in a human subject.

Lighting devices, systems, methods for stimulating circadian rhythms

The present invention provides reagents and methods for modulating cone photoreceptor activity, and devices for assessment of cone photoreceptor activity.

Reagents and methods for modulating cone photoreceptor activity

The present disclosure provides polynucleotide cassettes, expression vectors and methods for the expression of a gene in cone cells.

Compositions and methods for enhanced gene expression in cone cells

Eyeglasses are disclosed that include eyeglass frames and a pair of ophthalmic lenses mounted in the frames. The lenses include a dot pattern distributed across each lens, the dot pattern including an array of dots spaced apart by a distance of 1 mm or less, each dot having a maximum dimension of 0.3 mm or less, the dot pattern including a clear aperture free of dots having a maximum dimension of more than 1 mm, the clear aperture being aligned with a viewing axis of a wearer of the pair of eyeglasses.

Ophthalmic lenses for treating myopia

Methods and compositions are provided for intravitreally delivering a polynucleotide to cone photoreceptors. Aspects of the methods include injecting a recombinant adeno-associated virus comprising a polynucleotide of interest into the vitreous of the eye. These methods and compositions find particular use in treating ocular disorders associated with cone dysfunction and/or death.

Compositions and methods for intravitreal delivery of polynucleotides to retinal cones

Methods and reagents for determining a subject's predisposition for refractive error based on the presence of opsin gene exon 3 splicing defects are provided. In one aspect, the invention provides methods for determining a subject's predisposition for refractive error comprising: (a) testing a biological sample obtained from the subject to determine exon 3 splicing defects in one or more opsin gene; and (b) correlating the exon 3 splicing defects in the one or more opsin gene with a predisposition for refractive error.

Methods and reagents for predicting predisposition to refractive error

In a first aspect, the present invention provides methods for creating video signals including (a) receiving an input video signal including an input red component, an input green component, and an input blue component; (b) determining (i) that a magnitude of the input red component is greater than a magnitude of the input green component and (ii) a differential between the magnitude of the input red component and the magnitude of the input green component; and (c) sending an output video signal including an output red component, an output green component, and an output blue component, where at least one of the following is true: (i) the output red component is decreased by a fractional amount relative to the input red component based on the differential; and/or (ii) the output green component is increased by a fractional amount relative to the input green component based on the differential, and the output blue component is increased by a fractional amount relative to the input blue component based on the differential.

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Seattle, WA, United States of America

Jay Neitz