University of Florida Research Foundation, Incorporated

Florida Atlantic University

University of Southern California

The University of North Carolina at Chapel Hill

Memorial Sloan Kettering Cancer Center

University of Kansas

University of Health Sciences & Pharmacy in St. Louis

Jay McLaughlin

Predrag Cudic

Gavril W Pasternak

Bryan Leo Roth

Jane V Aldrich

Susruta Majumdar

Rajendra Uprety

Vsevolod Katritch

Sanjeewa Senadheera

Saheem Zaidi

Novel cyclic peptides, cyclic peptide conjugates and compositions containing them for treating neurological diseases in a subject include an Odorranalectin (OL) sequence or modified OL sequence as a scaffold and a biologically active peptide or protein and/or therapeutic agent conjugated thereto. Methods of treatment of neurological diseases are based on intranasal delivery of a cyclic peptide or cyclic peptide conjugate as described herein. Combinatorial libraries that include a plurality of cyclic peptides have also been developed and can be used to screen for a ligand(s) for a receptor of interest.

Cyclic peptides and cyclic peptide conjugates for treating neurological disorders

Methods of identifying opioid cyclic peptides

Cyclic peptide combinatorial libraries

The present technology provides compounds of Formula I (or pharmaceutically acceptable salts and/or solvates thereof) that are useful in treating a CNS-related disorder such as schizophrenia, schizoaffective disorder, migraine, depression, pain, drug addiction, drug use, and/or drug seeking behavior. Also provided are compositions, medicaments, and methods including such compounds.

Cyclic tetrapeptide analogs

In some aspects, the present disclosure provides compounds of the formula: wherein the variables are as defined herein. In some embodiments, these compounds may be used to reduce the pain of a patient. These compounds may be used in pain relief and show an improved pharmaceutical profile relative to other commonly used opiates and opioid derivatives.

G-protein biased opioid receptor agonist/analgesics with reduced arrestin recruitment

Cyclic peptides, cyclic peptide conjugates and methods of use thereof

Growing community of inventors

Gainesville, FL, United States of America

Jay McLaughlin