University of California

Otonomy, Inc.

Acucela Inc.

Dompe' Farmaceutici S.p.a.

Alk-AbellÓ, Inc.

Sirion Therapeutics, Inc.

Jay Lichter

Fabrice Piu

Carl Lebel

Andrew M Trammel

Luis A Dellamary

Qiang Ye

Jeffrey P Harris

Benedikt K Vollrath

Michael Christopher Scaife

Sergio G Duron

Kenneth J Widder

Sergio G Durón

Nathan L Mata

Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.

Auris formulations for treating otic diseases and conditions

Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

Controlled release antimicrobial compositions and methods for the treatment of otic disorders

Auris formulations for treating OTIC diseases and conditions

Disclosed herein are compositions and methods for the treatment of otic disorders with CNS modulating agent compositions and compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).

Controlled-release CNS modulating compositions and methods for the treatment of otic disorders

Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with aural pressure modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders

Disclosed herein are compositions and methods for the treatment of otic disorders with otic structure modulating compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).

Controlled-release otic structure modulating and innate immune system modulating compositions and methods for the treatment of otic disorders

Disclosed herein are auris acceptable gel compositions containing a multiparticulate glutamate receptor antagonist, and methods for the treatment of otic diseases or conditions through intratympanic administration of the composition to an individual afflicted with an otic disease or condition.

Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders

Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase ('ATPase') modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

Growing community of inventors

Rancho Santa Fe, CA, United States of America

Jay Lichter