Zoetis Services LLC

Pfizer Corporation

Zoetis LLC

Iowa State University Research Foundation, Inc.

Pharmacia & Upjohn Company

Pfizer Products Inc.

Zoetis P&u LLC

Zoetis P LLC

Jay Gregory Calvert

Siao-Kun Wan Welch

Douglas Steven Pearce

Michael G Sheppard

Jacqueline Gayle Marx

Robert G Ankenbauer

David Ewell Slade

James Richard Thompson

Marcia L Keith

Mira Ivanova Stoeva

Shelly Lynn Shields

Gregory Paul Nitzel

John Morgan Hardham

Qi Chen

Jianqiang Zhang

Phillip Gauger

Raymond R R Rowland

Dal-Young Kim

Dongwan Yoo

Changhee Lee

Donna Steuerwald Dunyak

Walter Valdez

Meggan Bandrick

Darin Madson

Xuemei Cao

Nancee Lois Oien

Michael K O'Hara

Michael G Shepard

Monica Balasch

Maria Fort

Nancee Lois Olen

Michael George Sheppard

The present invention is directed to novel nucleotide and amino acid sequences of Porcine Epidemic Diarrhea Virus ('PEDV'), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine PEDV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include polynucleotide constructs that replicate in tissue culture and in host swine. The invention also provides for novel full length PEDV genomes that can replicate efficiently in host animals and tissue culture.

Porcine epidemic diarrhea virus strains and immunogenic compositions therefrom

The invention provides isolated polynucleotide molecules that comprise a DNA sequence encoding an infectious RNA sequence encoding a genetically-modified North American PRRS virus, methods to make it and related polypeptides, polynucleotides, and various components. Vaccines comprising the genetically modified virus and polynucleotides and a diagnostic kit to distinguish between naturally infected and vaccinated animals are also provided.

Effective vaccination against porcine reproductive and respiratory syndrome (PRRS) virus prior to weaning

North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof

The present invention provides modified live European PRRS viruses (whether or not recombinant) that have been at all times cultured, maintained, and/or attenuated on non-simian cells, typically porcine cells, wherein such cells express a porcine CD163 receptor, and whereinby vaccines prepared from such viruses are safe and efficacious, and permit the pre-weaning single dose vaccination of swine, typically as early as Day 1 of life.

Effective vaccination against European strains of porcine reproductive and respiratory syndrome (PRRS) virus prior to weaning

The present invention provides methods and compositions related to the generation of host cells permissive for virus growth, particularly Porcine Reproductive and Respiratory Syndrome (PRRS) virus.

Cellular permissivity factor for viruses and uses thereof

The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus ('TTV'), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine TTV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include vaccines that provide TTV ORF1 protein, or peptide fragments thereof, as antigen.

Torque teno virus (TTV) isolates and compositions

Infectious clones of torque teno virus

Growing community of inventors

Otsego, MI, United States of America

Jay Gregory Calvert