University of Montana

Children's Medical Center Corporation

Jay Evans

David Burkhart

Kendal T Ryter

Alyson Jessica Smith

Helene G Bazin-Lee

George Ettenger

Ofer Levy

David J Dowling

Craig L Johnson

Helene Bazin-Lee

Walid Abdelwahab Marzouky Abdelwahab

Alyson Smith

Lipidated oxoadenines of formula (I) are TLR7/8 receptor ligands useful for modulating immune responses. The compounds may have therapeutic application in the treatment of cancer, infectious diseases, allergy, or autoimmnune disorders.

Vaccine adjuvants based on TLR receptor ligands

Disclosed herein are diaryl trehalose compounds and methods of use thereof, for example as vaccine adjuvants.

Diaryl trehalose compounds and uses thereof

Lipidated oxoadenines of formula (I) are TLR7/8 receptor ligands useful for modulating immune responses. The compounds may have therapeutic application in the treatment of cancer, infectious diseases, allergy, or autoimmune disorders.

Disclosed herein are immunogenic trehalose compounds and methods of use thereof, for example as vaccine adjuvants.

Immunogenic trehalose compounds and uses thereof

The methods and compositions described herein relate to methods of immunization or stimulating an immune response, e.g., using agonists of TLR7 and/or TLR8 as antigens. The methods and compositions described herein have particular relevance to use in infants.

Growing community of inventors

Corvallis, MT, United States of America

Jay Evans